Phytochemical Evaluation And Pharmacological Screening Of Antiparkinson’s And Laxative Activities Of Hylocereus Undatus (White Pitaya) In Rodents
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
Objective: To evaluate the antiparkinson’s and constipation activity of Hylocereus undatus Haw. fruit extract in haloperidol induced parkinson’s disease and loperamide induced constipation in mice. Method: Parkinson’s disease was induced by administering haloperidol daily for a week. The mice were divided into five groups (n=6).Group I received 0.9% Normal saline (10ml per kg), Group II received Haloperidol (2 mg/kg i.p), Group III received combination of Levodopa and Carbidopa (100mg + 10mg per kg i.p along with haloperidol) and Group IV and Group V received ethanolic extract of Hylocereus undatus (200 and 400mg/kg p.o), respectively for 7 days along with haloperidol. To evaluate antiparkinson’s activity of Hylocereus undatus, Catalepsy bar test, Rota rod test, Hang test, Horizontal bar test, Actophotometer test were used. One way ANOVA was used to test statistical significance followed by Bonferroni multiple comparison tests. Constipation was induced by administration of loperamide. The mice were divided into 5 groups (n=6). Group I received 0.9% Normal saline (10ml per kg ) ,Group II received loperamide (5mg/kg p.o), Group III received bisacodyl (20 mg/kg p.o along with loperamide) and Group IV and Group V received ethanolic extract of Hylocereus undatus (200 and 400mg/kg p.o), respectively along with loperamide. To evaluate Constipation activity, Number, weight and % of faecal matter were studied. One way ANOVA was used to test statistical significance followed by Tukey’s model test. Result: Hylocereus undatus extract was found to decrease the duration of catalepsy significantly (P < 0.001) catalepsy bar test as compared to Haloperidol group and significantly increases (P < 0.001) fall off time in Rota rod test, Hang test, Horizontal bar test and increase count in Actophotometer test respectively as compared to Haloperidol group. Hylocereus undatus extract was found to increase the number of faecal matter, faecal weight and decrease in the water content of faeces which were indication of laxative activity of Hylocereus undatus. Conclusion: The result of the study shows the Antiparkinson’s and Constipation activity of Hylocereus undatus.
Authors and Affiliations
P. Kanchana*,, S. K. S. V . Devi1 ,, P. Pushpa latha2, N. Spurth .
Keywords
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