Phytochemical Screening, Analgesic And Anti-Inflammatory Activities Of Methanol Stem Bark Extract Of Senna Siamea Lam. (Kassod Tree)
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
The study aims at phytochemical screening, analgesic and anti-inflammatory activities of methanol stem bark extract of Senna siamea Lam. (kassod tree). Fresh stem bark of Senna siamea were air-dried, pulverized extracted using maceration method of extraction technique with methanol and yielded 12.60 %. w/w after being concentrated. The extract was screened for phytochemicals using standard methods. The phytochemical studies of the methanol extract of Senna siamea revealed the presence some chemical compounds such as alkaloid, flavonoids, cardiac glycosides, tannins, saponins, and terpenoids. The analgesic effect of the leaf extract was evaluated with acetic acid induced writhing and thermally induced nociception for pain while the antiinflammatory effect was evaluated using albumin-induced rat paw oedema model. The LD50 of the stem bark extract was ≥5000 mg/kg. The methanol stem bark extract of Senna siamea caused an inhibition on the writhing response induced by acetic acid in a dose dependently. Similarly, the extract doses increased the time of tail flicking in a dose dependent manner. The stem bark extract also significantly (P < 0.05) inhibited inflammation induced by egg albumin in the rats paw. Thus, this study has scientifically justified that the plant possess some degree of action on peripheral and central nervous system thereby acting as an antidepressant in suppressing pain and inflammation. The proves the use of the plant locally for the management and treatment of pain related health problems.
Authors and Affiliations
Sodipo O. A, Tijjani. , M. A. , Yakubu, J, Abdulrahman, F. I, Salwa M. Mohamed
Keywords
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