Phytochemical Screening and In vitro Evaluation of Cytotoxic Activity of Fruits of Lagerstroemia speciosa L.
Journal Title: Scholars Academic Journal of Biosciences - Year 2014, Vol 2, Issue 12
Abstract
The objective of the present work is to evaluate the cytotoxic activity of fruits (without seeds) of Lagerstroemia speciosa L. Based on this, a new series of constituents had been planned to extract by Methanol (ML), Ethanol (EL), Chloroform (CF) from the fruits of Lagerstroemia speciosa L. The in-vitro cytotoxic activities were carried out against two human cancer cell lines such as Human Acute Monocytic Leukemia- HL- 60 cell line and Human Colon Cancer- DLD-1 cell line and MTT assay was used to analyze the cell growth inhibition of the both and doxorubicin was used as a standard drug for the HL-60 cell line and 5- Flurouracil was used for DLD-1 cell line. The results showed that the various extracts of fruits of Lagerstroemia speciosa L had a very good to moderate cytotoxic activity against both HL- 60 and DLD-1 cell lines and it was also reported that the CF extracts had shown the highest cytotoxic activity against both cell lines among the three extracts. The IC50 values of the various extracts of fruits of Lagerstroemia speciosa L were found to be ML (IC50 of 3.4µg/ml), EL (IC50 of 3.9µg/ml), CF (IC50 of 2.3µg/ml) for HL- 60 cell line and ML ( IC50 of 3.2µg/ml), EL (IC50 of 3.8µg/ml), CF (IC50 of 2.2µg/ml) for DLD-1 cell line.
Authors and Affiliations
Asish Bhaumik, M. Upender Kumar, Ch. Monogna, Kaleem Ahmed Khan, M. Uttara
Keywords
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