PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES OF CRATEVA ADANSONII EXTRACTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 9
Abstract
Objective: This study aims to search the secondary metabolites of Crateva adansonii (leaves and bark) and evaluate some biological activities (antimicrobial, antioxidant and cytotoxicity’s property) of these extracts.Methods: The phytochemical screening was made with standard method. Agar diffusion method was used for antibacterial activity coupled with Minimum Inhibitory Concentration (MIC) and Bactericidal (MBC) determination. The antifungal test was performed by the mycelial development reduction method. DPPH method was used to evaluate the extracts antioxidant activity. Artemia salina larvae were use as support to evaluate the toxicity of the extracts.Results: The results of the phytochemical screening reveal the presence of polyphenols, triterpenoids, and glycosides in the both organs (leaves and bark) of C. adansonii. All the extracts have low activity on the reference strains with a larger diameter of 17±00 mm (S. oralis). Only the ethanolic and hydroethanolic leaf’s extracts inhibited respectively 20% and 10%, of the clinical strain S. aureus. The ethyl acetate leaf’s extract shows the best antifungal activity (89,19%) with A. clavatus. All extracts present dose-dependent antiradical properties and are non-toxic for the cells of Artemia salina. C. adansonii bark extracts had the best reducing power (23,80±0, 137 mmol/g EqAA EAA) of the DPPH radical.Conclusion: C. adansonii is therefore an active principle source for the development of drugs to antimicrobial and antioxidant activities
Authors and Affiliations
Martial S. Nounagnon, Durand Dah-nouvlessounon, Christine N’tcha, Boris Legba, Farid Baba-moussa, Adolphe Adjanohoun, Lamine Baba-moussa
Keywords
Related Articles
- EP ID EP566159
- DOI 10.22159/ijpps.2018v10i9.27197
- Views 84
- Downloads 0
EVALUATION OF ANTI-CML ACTIVITY OF METHANOL AND AQUEOUS EXTRACTS OF BENKARA MALABARICA (LAM.) TIRVENG PLANT LEAVES
Objective: To investigate the phytoconstituents and in vitro cytotoxicity of methanol (MeOH) and aqueous (AQE) extracts of Benkara malabarica (Lam.) Triveng (BM) plant leaves.Methods: Gas chromatography-mass spectrometry...
COMPARATIVE ANALYSIS OF THE IN VITRO ANTIOXIDANT ACTIVITY AND POLYPHENOLIC CONTENT OF SUCCESSIVE EXTRACTS OF NYCTANTHES ARBOR-TRISTIS LINN.
Objective: Present work comprehensively evaluates the antioxidant capacity, total phenolic content (TPC) and total flavonoid content (TFC) of four successive extracts of various parts of Nyctanthes arbor-tristis Linn. at...
IN VITRO DIGESTIBILITY OF THE DROMEDARY WHEY PROTEINS: POTENTIAL USES IN INFANT MILK ALLERGIES
Objective: Dromedary milk has a good nutritive value and is free of b-lactoglobulin (b-Lg), which is considered one of the major antigens of cow’s milk proteins responsible for the incidence of allergy in infancy. In t...
EVALUATION OF ANTI-RENOTOXIC RESPONSES IN FLOWERS OF INDIAN LOTUS (NELUMBO NUCIFERA GAERTN.)
Objective: The present study was formulated in order to evaluate anti-renotoxic responses in flowers of an Indian lotus (Nelumbo nucifera Gaertn.)Methods: Gentamicin at a dose of 100 mg/kg/day was used intra-peritonealy...
MODIFICATION OF GUMS BY PERIODATE OXIDATION: A NATURAL CROSS-LINKER
Scientists throughout the world are in search of novel modified biopolymer to fabricate smart drug delivery systems based on hydrogel formulations using several cross-linkers like glutaraldehyde, glyoxal, epichlorhydrin,...