Piecewise polynomial regression model for interpretation of risperidone depot concentration versus time data
Journal Title: Archives of Psychiatry and Psychotherapy - Year 2016, Vol 18, Issue 1
Abstract
Risperdal ConstaTM (risperidone) was the first long-acting depot formulation of an atypical antipsychotic belonging nowadays to standard treatments for schiz-ophrenic patients. The microsphere technology of this depot formulation re-sults in a complex pharmacokinetics with a delay (lag time) of relevant drug levels for 3 to 4 weeks, which therefore initially requires additional oral doses. The piecewise polynomial regression approach based on sign functions was used to define the complex concentration versus time curve after a single in-tramuscular injection. A 3-phase linear model with logarithmic transformation of concentration data was suited to fit the concentration time data and gave valuable data on both half-lives and phase borders (deflection points).
Authors and Affiliations
Horst Koch
Keywords
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