Pilot study of salivary butyrylcholinesterase, phosphodiesterase, thiols and cerulopalsmin in auditory neuropathy
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To estimate butyrylcholinesterase (BChE), phosphodiesterase (PDE), thiols and cerulopalsmin by non - invasive means in saliva a of subjects (both cases and controls) and correlated to their hearing sensitivity. Methods: Total of 13 subjects participated in this study. Among them 7 were having auditory neuropathy and 6 were healthy controls. Unstimulated saliva (10 ml) was collected from each participant. Ceruloplasmin , thiols, phosphodiesterase and pseudocholinesterase were estimated by colorimetric method in the salivary samples. Results: Salivary BChE and PDE levels were marginally elevated and protein thiols were marginally decreased in cases as compared to that of controls. Salivary ceruloplasmin was significantly decreased (p = 0.022) in cases as compared to that of controls. Conclusions: Saliva can be used as a potential noninvasive tool for evaluation of disorders.
Synthesis, biological evaluation, QSAR analysis, and molecular docking of chalcone derivatives for antimalarial activity
Objective: To synthesize chalcone derivatives and investigate their antimalarial activity toward chloroquine-sensitive Plasmodium falciparum 3D7 (Pf3D7) strain; to develop quantitative structureactivity relationships (QS...
Curcumin profiing and genetic diversity of different accessions of Curcuma longa L.
Objective: To investigate the genetic diversity and variation in active compound of turmeric rhizomes collected from different niches of Uttarakhand. Methods: Genetic diversity and relationship of Curcuma longa accession...
Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency
Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with dia...
Development of a multiplex polymerase chain reaction protocol for the simultaneous detection of Salmonella enterica serovar Typhi and Class 1 integron
Objective: To develop a multiplex polymerase chain reaction (PCR) protocol for the simultaneous detection of Salmonella enterica serovar Typhi (S. Typhi) and Class 1 integron, so as to aid rapid diagnosis of S. Typhi cas...
Central nervous system infections at the Hospital Universitario de Santander: An autopsy study in the period of 2004–2015
Objective: To describe the neuropathological findings in autopsy performed for individuals with CNS infections and compare the data obtained with the information referred in the literature. Methods: We reviewed the proto...