piRNAs: the "Bodyguards" of Fertility
Journal Title: Journal of RNA and Genomics - Year 2017, Vol 13, Issue 1
Abstract
Among the small non coding RNAs classes, piRNAs are of particular interest because of their role in allowing the normal reproduction of individuals, from Drosophila to mouse. The reduction of piRNAs in the germ cells is sufficient to cause the sterility of fruit flies. This damaging effect arises from the spread of transposable elements, normally silenced by the piRNAs, into the genome. The DNA damages caused from mobile elements are directly related to the reproductive deficits.
Authors and Affiliations
Valeria Specchia
Keywords
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