Pitfalls in Diagnosing Seropositive Rheumatoid Arthritis: Haematologic Malignancy Presenting as an Autoimmune Disease
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Carcinomatous Polyarthritis (CP) is defined as the development of arthritis in association with a malignancy but distinct from that associated with metastasis or direct invasion. It can occur before, with, or after onset of malignancy or with treatment. CP usually affects large joints and is negative for Anti Citrullinated Protein Antibodies (ACPA). CP is rarely if ever considered in the differential diagnosis of a case of symmetric polyarthritis with ACPA positivity. Presence of autoimmune disease related antibodies further obscures the diagnosis. We present a case of a young lady with symmetrical inflammatory polyarthritis with positive ACPA who was found to have haematological malignancy. This is one of the very few cases of CP of small joints with ACPA positivity reported worldwide and highlights the need to be vigilant for red flags while evaluating any case presenting with rheumatologic symptoms.
Authors and Affiliations
Bijit Kumar Kundu, Eashan Srivastava, Vijesh Vijayan, B Manojprabhakaran, Mukesh Verma
Keywords
Related Articles
- EP ID EP511223
- DOI 10.7860/JCDR/2018/32391.11284
- Views 74
- Downloads 0
Addison’s Disease Mimicking as Acute Pancreatitis: A Case Report
Over past two decades there has been significant improvement in medical field in elucidating the underlying pathophysiology and genetics of Addison’s disease. Adrenal insufficiency (Addison’s disease) is a rare disease w...
Assessment of Insulin Sensitivity and its Convalescence with Dietary Rehabilitation in Undernourished Rural West Bengal Population
Introduction: Metabolic syndrome involving diabetes is acquiring the eminence of prospective epidemic in India with dramatic rise in rural population prevalence where majority are undernourished and creates significant h...
Screening for Postpartum Depression in a Neonatal Intensive Care Unit and Postnatal Ward with Its Impact on Newborn Care Practices: A Hospital Based Survey
ABSTRACT Introduction: Depression is the fourth leading cause of disability and is estimated to rise to second place by the year 2020. Women of child bearing age are at an increased risk of depression, with an even highe...
Local Injection of Triamcinolone Acetonide: A Forgotten Aetiology of Cushing’s Syndrome
Many different non systemic corticosteroid administrations can cause iatrogenic Cushing’s Syndrome (CS). We herein report a case series of iatrogenic CS from keloid scars treatment and aesthetic regimen called mesotherap...
Indwelling J Ureteral Stents Associated Asymptomatic Bacteraemia Caused by Multidrug Resistant Strain of Kocuria kristinae
ABSTRACT Kocuria kristinae is a Gram positive non pathogenic bacterium belonging to the family of micrococcacae. It may cause opportunistic infections in patients with indwelling devices and severe underlying diseases. I...