PIVKA II as an Indicator of Vitamin K Deficiency in Children of the First Months of Life, Exclusively Breastfed Ukrainian Research
Journal Title: Здоров`я дитини - Year 2016, Vol 7, Issue 75
Abstract
Background. Breastfed infants and babies in their first months of life especially, are naturally prone to a deficiency of vitamin K. The aim of our research was to clarify the frequency of determination, within the Ukrainian population, of full-term breastfed children aged up to six months of life with higher concentrations of PIVKA II — protein induced by an absence of vitamin K in order to study the modern circumstances behind the deficiency of vitamin K. Materials and Methods. The entities of the research were the samples of serum obtained from 180 children aged 1 day to 6 months old, all born full term with a mass from 2800 to 4200 grams and an Apgar score 7–10. All these children were breastfed from the day of their birth. Results. As our monitoring shows, more than 50 % of the infants were affected by vitamin K deficiency, according to the positive results of the Elisa tests that detected carboxylated prothrombin (PIVKA II) in the serum. According to the PIVKA II tests, the greatest proportion of positive results is found among newborns, which shows that the hypovitaminosis occurs in utero. Conclusions. The amount of vitamin K, necessary to the synthesis of protein chains that are essential to a newborn’s organism is insufficient among more than half a subpopulation of full term born infants in the Southern region of Ukraine. The principles of this phenomenon are due to idiopathic antenatal reasons, the rejection of the preventive vitamin K injection after birth, full-term breastfeeding, a deficiency of menaquinone and phylloquinone, a microbial imbalance of gut flora, which is important for the creation of the menaquinone pool that provides vitamins to overcome their deficient state in early childhood.
Authors and Affiliations
O. G. Ivanko, A. V. Solyanik
Keywords
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- EP ID EP182490
- DOI 10.22141/2224-0551.7.75.2016.86732
- Views 67
- Downloads 0
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