Placental changes in patients of asthma and tuberculosis with relation to fetal outcome
Journal Title: Medpulse International Journal of Gynaecology - Year 2018, Vol 7, Issue 2
Abstract
Background: The potential benefits of placental examination include clarification of pathological features, improved management of subsequent pregnancies. Aim: To study the placental changes in patients of asthma and tuberculosis with relation to fetal outcome. Material and Methods: Among the 200 placentae from patients having medical disorders, 13 were from asthma patients and three were from tuberculosis patients. The cases of uncomplicated pregnancies not having any medical disorder in pregnancy were considered as control group. Patients with clinical diagnosis of Asthma (those using low or high dose glucocorticoids regularly and those not using glucocorticoids regularly for relief of symptoms) and tuberculosis were considered as cases. Results: The caseous lesions were seen in 66.66% of TB cases which were not seen in any of control group patients. Increased syncytial knots, fibrinoid degeneration and hypervascular villi were seen in 33.33% of TB cases Microscopic pathologies like fibrinoid degeneration, stromal fibrosis, hypovascularisation of villi were seen significantly in cases of asthma using glucocorticoids regularly for relief of their symptoms as compared to cases who use steroids occasionally for relief of their symptoms and control group. There was one case (33.33%) of perinatal death in tuberculosis patient. No perinatal death was seen in asthmatic cases. Conclusion: Exacerbations of asthma specifically increases the risk of adverse perinatal outcomes. The differential diagnosis of acute villitis and intervillitis in the placenta should include tuberculosis. The placental examination improves the management of subsequent pregnancies.
Authors and Affiliations
Shailendra V Mangnale, Ashwini S Mangnale
Keywords
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