Plasma olanzapine concentration: Relation with dose, adherence to medication, and clinical efficacy
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 3
Abstract
Objective To estimate plasma olanzapine concentration POC using liquid chromatographymass spectrometry LCMS and identify factors that contributes to pharmacokinetic variability of olanzapineMaterials and Methods This was a prospective observational study initiated after approval of institutional ethics committee Stable patients of schizophrenia on olanzapine above 18 years of age of either gender on olanzapine therapy for at least 12 weeks with no change in dose for at least one week were included Plasma levels of olanzapine were assessed using HPLC based kit on LCMS To assess response to treatment patients were subjected to Brief Psychiatric Rating Scale BPRS in which lower score indicates better response Adherence to therapy was assessed by using Morisky 8Item Medication Adherence Questionnaire in which lower score indicates better adherence Graph pad prism version 60 was used for statistical analysisResults POC was higher in women compared to men No correlation was observed between POC and age r 001343 p 09470 or daily dose of olanzapiner 02765 P 01626 Patients having POC more than 20 ngml had better adherence Moriskys score 1 or 2 to medication compared to those having POC less than 20 ngml Significant correlation was observed between POC and clinical responser 04371 p00226Conclusion TDM of olanzapine is important considering large interpatient variability in POCs at the same dosages It can also help in improving efficacy particularly when patients do not respond to therapeutic doses or when they develop adverse effects Cost of the procedure is a major concern which needs to be considered before this can be established in routine practiceKeywords TDM Antipsychotics BPRS LCMS Schizophrenia
Authors and Affiliations
Vijay Motghare, Smita Sontakke, Ritu Budaniya, Kundan Niwangune, Avinash Turankar
Keywords
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- EP ID EP478558
- DOI 10.18231/2393-9087.2018.0027
- Views 66
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