Plasma Omentin-1 Level and its Relationship with Insulin Resistance in Obese Prediabetics
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 4
Abstract
ABSTRACT Introduction: Omentin-1 is an adipokine expressed, predominantly in visceral fat and has insulin sensitising effects. However, its levels in obese prediabetics have not been evaluated so far in India. Aim: To evaluate plasma levels of omentin-1 in obese prediabetic, obese normoglycaemic and healthy individuals and to explore correlation of omentin-1 with measures of obesity and insulin resistance. Materials and Methods: The present case control study was conducted on 150 males from medical OPD of hospital. Based on anthropometrical measurements and Oral Glucose Tolerance Test (OGTT) with 75 g of anhydrous glucose, three groups of 50 males each (20-50 years) were selected. Group-1 included healthy controls, Group-2 obese normoglycaemic and Group-3 obese prediabetic subjects. Fasting and postprandial plasma glucose, HbA1c, fasting serum insulin, plasma omentin-1 and lipid profile was investigated. Insulin resistance was calculated by Homeostatic Model of Insulin Resistance (HOMA-IR). Statistical analysis was carried out by SPSS statistics software using one-way ANOVA followed by Tukey’s test at 5% level. Pearson’s correlation coefficient was used for calculation of association of variables. Results: We found that plasma omentin-1 levels were decreased significantly in obese prediabetics (228.7±13.4 ng/mL) compared to obese normoglycaemic (298.4±79.8 ng/mL) and healthy control (408.0±98.9 ng/mL) (p<0.05). Fasting insulin levels were higher in obese prediabetics (11.2±3.20 μU/mL) compared to obese normoglycaemic (8.4±4.78 μU/mL) and healthy controls (5.5±2.90 μU/mL). Obese prediabetics had altered lipid profile. HOMA-IR was higher in obese prediabetics, compared to other two groups. Plasma omentin-1 levels showed negative and significant correlation with HOMA-IR (p<0.05). Conclusion: Concentration of plasma omentin-1 decreased and insulin resistance increased in obese prediabetics compared to obese normoglycaemics and healthy controls. As omentin-1 increases sensitivity to insulin, its decreased levels may be responsible for impaired glucose homeostasis in obese prediabetics.
Authors and Affiliations
Nalini Kaushik, Ravi Kaushik, Piyush Dixit, Mool Kumar Tyagi, JK Gambhir, SV Madhu, Rimi Shukla
Keywords
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- EP ID EP522304
- DOI 10.7860/JCDR/2018/31845.11432
- Views 54
- Downloads 0
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