Plasmablastic Lymphoma: A Diagnostic Dilemma
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2013, Vol 15, Issue 1
Abstract
Plasmablastic lymphoma (PBL) has been described as a rapidly progressive and fatal, CD20 negative, CD138 positive diffuse large cell lymphoma with plasmoblastic features. PBL is heterogenous in terms of clinical presentation and morphological features. Morphologically and immunophenotypi cally its close differential diagnosis is plasmablastic myeloma, especially at extramedullary sites. Here, we present two cases with identical morphological and immunophenotypic profile but have different clinical presentation leading to different diagnoses. Case 1 had classical presentation of PBL (HIV positive, oral mucosal involvement), whereas case 2 was HIV negative woman presented with multiple myeloma, who later on developed a lesion in lower alveolus. Both cases showed similar morophological and immunophenotypical features, but they were diagnosed as plasmoblastic lymphoma and plasmoblastic myeloma respectively.
Authors and Affiliations
Jahnavi Gandhi, Trupti Patel, Hiral Shah, Priti Trivedi, Manoj Shah
Keywords
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