PLASMODIUM PARASITAEMIA IN SICKLERS AND NON-SICKLERS ATTENDING THE GENERAL HOSPITAL CALABAR, SOUTH- SOUTH NIGERIA: A CROSS-SECTIONAL STUDY
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 9
Abstract
Malaria remains a public health problem in countries of the world where the disease is prevalent. In 2015 alone, it accounted for 429,000 deaths globally according to World Health Organization report. 92% of these deaths occurred in the Africa region. Sickle cell disease is common in people of African descent and in other areas of the world where malaria is prevalent. Epidemiological studies have established an association between Plasmodium falciparum and sickle cell states. Studies have shown that the heterozygous state (HbAS) confers a protective advantage against malaria attacks and its lethal complications which is not seen in the homozygous state (HbSS) and in subjects with normal haemoglobin (HbAA). The mechanism that underpins this phenomenon has been the subject of scientific enquiry for over six decades. 100 subjects with malaria symptoms attending the outpatient’s clinic of the General Hospital Calabar were purposively selected and enlisted for the study which was done between December 2015 and February, 2016. Finger- pricked blood sample was obtained for slide smears, PCV and genotype of participants which comprised 34 persons with normal haemoglobin (HbAA), 34 with HbAS while 30 had HbSS. Only10 out of the 34 carriers (29%) had parasitaemia as against 83% each of those with HbAA and HbSS. The mean parasite count for HbAA subjects (2126, SD1319) was twice as high as that for HbSS (1083, SD729) and seven times higher than in subjects with HbAS (286, SD55). Parasitaemia was significantly associated with genotype with AS being the least likely to be infected (Chi Square 28.68, df 2, and p-value 0.000). We concluded that the carrier state AS protects both against parasitaemia and heavy parasite density.
Authors and Affiliations
Oden E. M.
Keywords
Related Articles
- EP ID EP665512
- DOI -
- Views 152
- Downloads 0
UDAVARTHINI YONIVYAPAT AND ITS MANAGEMENT – CONCEPTUAL STUDY
The reproductive process in woman is a complex and highly evolved interaction of many components. Disturbance in any component can cause problems in menstrual cycle; one being is dysmenorrhoea which affects most of the w...
INCIDENTALLY DIAGNOSED HYDATID CYST - A CASE REPORT
Hydatid disease, caused by the parasite Echinococcus granulosus, mostly affects the liver and the lungs with hydatid cysts which consist of three layers: (1) the outer pericyst; (2) the middle laminated membrane; and (3)...
ESSENTIAL MEDICINES AND COMMODITIES FOR REPRODUCTIVE HEALTH: REPRESENTATION ON THE 2010 NIGERIA ESSENTIAL MEDICINES LIST
Background: Appropriately selected essential medicines lists target the prioritised health needs of any population. International standards have been set for such lists with Nigeria apparently complying with such standar...
TOTAL CHOLESTEROL AND HDL RATIO IN NORMOGLYCEMIC OFFSPRING OF PATIENT WITH T2DM ON GRADED EXERCISE
Objectives: The primary causes of Type 2 Diabetes Mellitus (T2DM) are largely unknown but increase in Total Cholesterol and HDL ratio (TC and HDL ratio) has been reported to be a risk factor for the T2DM through the alte...
DETAILED STUDY OF PROSTATE GLAND, IT’S DISEASES AND TREATMENT ACCORDING TO AYURVEDA
All people are made up of saptdhatus, but due to different stages of life, males and females have different organs from each other in their body. That’s why males and females have different problems and diseases from eac...