Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 12
Abstract
Introduction: Platelets from patients with type 1 and type 2 diabetes exhibit enhanced platelet aggregation activity early in the disease course that may precede the development of cardiovascular diseases. Both atherosclerosis and thrombosis appear to contribute significantly to the increased cardiovascular risk of diabetic patients. Platelet indices include mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). This study was undertaken with the aim to find out the differences in platelet indices between diabetics and non-diabetics and also between patients with controlled and uncontrolled diabetes mellitus in a tertiary health care centre in North East India. Methods: This is a cross sectional study conducted in Agartala Government Medical College and GB Pant Hospital (AGMC & GBP Hospital). 100 cases and 100 controls were selected from the Diabetes clinic of Medicine out patient department (OPD) and Medicine wards. Platelet indices and HbA1C levels of these cases and controls were measured. Platelet indices were measured by a 3-part differential hematology auto-analyzer and HbA1C by High Performance Liquid Chromatography (HPLC) method. Blood glucose levels were estimated by oxidase-peroxidase method. Results: Platelet indices were found to be significantly higher among diabetics compared to non-diabetics and also they were found higher among patients with poor glycemic control with HbA1C>7% in comparison to patients with good glycemic control with HbA1C<7% (P value <0.05). Conclusions: Platelet indices are significantly increased in diabetics and the extent of increment is more in diabetics with poor glycemic control.
Authors and Affiliations
Prasun Bhattacharjee, Abhijit Datta, Rajesh Kishore Debbarma, Swapan Kumar Das
Early CRRT and antibiotic management in shock patient due to urosepsis with immunocompromised post renal transplantation
Septic shock is a major cause of morbidity and mortality in the ICU. A 32-year-old patient was diagnosed with septic shock due to urosepsis, hospital-acquired pneumonia (HAP), and acute kidney injury (AKI) post renal tra...
To study maternal mortality and complications leading to maternal death in the tertiary care centre
Objective: To study maternal mortality and complications leading to maternal death in the tertiary care centre over the five years of period. Method: A retrospective and prospective study of all maternal deaths from Janu...
Study of clinical profile and management of vitreous haemorrhage
Background: Vitreous haemorrhage is one of the common causes of visual loss. This study reports a clinical profile and management of vitreous haemorrhage in our environment, which prevent complications so as to avoid irr...
Perception of objective structured clinical examination and traditional practical examination in assessment of nursing students clinical competencies by nursing students in south west Nigeria
Background: Clinical examination is a crucial part of nursing training programmes for assessing nursing student competencies which ultimately lead to the delivery of quality nursing care. Two methods of clinical assessme...
Clinicoradiological and demographic pattern in diffuse parenchymal lung diseases: An observational study
Introduction: Diffuse parenchymal disease is a group of lung disease affecting alveolar epithelium, pulmonary capillary endothelium, basement membrane, perivascular and perilymphatic tissue. It includes many diseases lik...