Platelet Rich Plasma- mechanism of action and clinical applications
Journal Title: Journal of Clinical and Investigative Surgery - Year 2016, Vol 1, Issue 2
Abstract
Platelet-rich plasma (PRP) is a blood-derived fraction containing high level of platelets, a high concentration of leukocytes and growth factors. PRP therapy has been growing as a viable treatment alternative for a number of clinical applications and has a potential benefit for use in wound healing. Nowadays platelet rich plasma is used in stimulating wound healing in skin and soft tissue ulcerations, accelerating wound healing in diabetic patients and facilitating bone proliferation in orthopedic and trauma surgery. It has also applications in maxillofacial surgery, spinal surgery, plastic and esthetic surgery, heart surgery and burns. This review of the literature shows a limited number of studies realized on humans that sustain PRP applications in orthopedic and plastic surgery. As the use of PRP increases, more properly structured clinical studies are necessary to confirm the results and to establish clearly the techniques of preparing, the conditions and the clinical indications of applying this therapy.
Authors and Affiliations
Cristina N. Cozma, Laura Raducu, Cristian R. Jecan
Breast sarcoma surgical management: a five-year multicentric study
Background. Breast sarcomas are a heterogeneous group of breast neoplasms with a low incidence and a reserved prognosis. No treatment protocol has been yet established, a guideline similar to soft tissue sarcomas is used...
Diagnostic and treatment difficulties in Crohn's disease
Inflammatory bowel diseases are related to a special pathology having a great psychosocial and economic impact, being represented by chronic diseases which often affects the adult/ active population and that require a lo...
Gallstone ileus - the double challenge: case report and review of the literature
Gallstone ileus is a rare condition which occurs as an evolutive complication of biliary lithiasis. It occurs after stone migration from extrahepatic biliary tree to the digestive lumen, mostly through a biliary-enteric...
Open versus arthroscopic surgery in acromioclavicular separation
Acromioclavicular separation is a very serious injury at the level of shoulder. Lesion of the acromioclavicular joint is a usual clinical condition because of its superficial situation. It is often involved in trauma of...
Subcutaneous metastasis from endometrial cancer; case report and literature review
Subcutaneous metastases from endometrial cancer are rare situations, only few cases being described so far. The main incriminated mechanisms leading to the apparition of such lesions include hematogenous and lymphatic sp...