Platelets and the clinical course of Crohn’s disease
Journal Title: Health Problems of Civilization - Year 2018, Vol 12, Issue 4
Abstract
Background Crohn’s disease (CD) is a chronic, autoimmune, inflammatory bowel disease (IBD) characterised by periods of exacerbations and remissions. Autoimmune disorders caused by undetermined factors lead to inflammation in the intestinal mucosa. Presently, there is a growing interest in the role of platelets in the assessment of inflammatory lesions in CD. Accordingly, the aim of this study was to answer the question of whether routinely measured platelet indices: concentration of platelets (PLT), the mean platelet volume (MPV), plateletcrit (PCT) could become biomarkers for monitoring the course of CD. Material and methods In the study programme, there were enrolled 100 patients with a diagnosed CD with a different clinical course, disease location and heterogeneous therapy. In all patients, there were collected blood and stool samples for the assessment of CRP, blood count and fecal calprotectin evaluation. The clinical state of each patient was classified using the Harvey-Bradshaw index. Results The study showed a positive, statistically significant correlation between fecal calprotectin, CRP, WBC, the Harvey-Bradshaw index and the number of platelets and PCT. Furthermore, the analysis showed a statistically significant negative correlation between MPV and the number of WBC, CRP and fecal calprotectin. Conclusions Our study showed that platelet indices are a valuable, non-invasive and widely accessible method to assess mucosal healing and the clinical status of the patient.
Authors and Affiliations
Milena Padysz, Krystyna Stec-Michalska, Julia Banasik, Anita Gąsiorowska
Keywords
Related Articles
- EP ID EP477740
- DOI 10.5114/hpc.2018.78783
- Views 54
- Downloads 0
NUTRITIONAL HABITS AND PHYSICAL ACTIVITY OF THE YOUTH OF LATVIA CONSIDERING GENDER DIFFERENCES
Introduction. Nutritional habits and physical activity are fundamental for a healthy lifestyle. The aim of the paper is to present differences in the area of important pillars of health taking into account youth’s gender...
SELECTED ELEMENTS OF LIFESTYLE IN RELATION TO THE LEVEL OF A NON-SPECIFIC PAIN OF THE CERVICAL SPINE IN PERSONS AGED 20-35 YEARS
Background. Non-specific back pain indicating serious distant health and social consequences is an important challenge for both health promotion and prevention programs. Material and methods. The study was conducted 150...
NEW ASPECTS IN THE TREATMENT OF HYPERTENSION
Hypertension is currently the leading cause of cardiovascular complications [heart attack, stroke] and the resulting deaths of patients. Reduced morbidity and mortality from cardiovascular complications is the main goal...
OPTIMIZATION OF PHARMACOTHERAPY SYSTEM FOR TREATMENT OF THYROID DISEASES IN UKRAINE
Background. Recent years thyroid diseases are attracting considerable attention. On one hand, this is due to the fact that thyroid is actively reacts on environment, followed by appearance of various diseases. On the oth...
Migration from Northern Siberia regions: psychophysiological adaptation of children
Background This article presents results of research about psychophysiological adaptation of children who migrated from the northern to the southern regions of Siberia. The purpose of this study was to create measures th...