Platelets and the clinical course of Crohn’s disease
Journal Title: Health Problems of Civilization - Year 2018, Vol 12, Issue 4
Abstract
Background Crohn’s disease (CD) is a chronic, autoimmune, inflammatory bowel disease (IBD) characterised by periods of exacerbations and remissions. Autoimmune disorders caused by undetermined factors lead to inflammation in the intestinal mucosa. Presently, there is a growing interest in the role of platelets in the assessment of inflammatory lesions in CD. Accordingly, the aim of this study was to answer the question of whether routinely measured platelet indices: concentration of platelets (PLT), the mean platelet volume (MPV), plateletcrit (PCT) could become biomarkers for monitoring the course of CD. Material and methods In the study programme, there were enrolled 100 patients with a diagnosed CD with a different clinical course, disease location and heterogeneous therapy. In all patients, there were collected blood and stool samples for the assessment of CRP, blood count and fecal calprotectin evaluation. The clinical state of each patient was classified using the Harvey-Bradshaw index. Results The study showed a positive, statistically significant correlation between fecal calprotectin, CRP, WBC, the Harvey-Bradshaw index and the number of platelets and PCT. Furthermore, the analysis showed a statistically significant negative correlation between MPV and the number of WBC, CRP and fecal calprotectin. Conclusions Our study showed that platelet indices are a valuable, non-invasive and widely accessible method to assess mucosal healing and the clinical status of the patient.
Authors and Affiliations
Milena Padysz, Krystyna Stec-Michalska, Julia Banasik, Anita Gąsiorowska
Keywords
Related Articles
- EP ID EP477740
- DOI 10.5114/hpc.2018.78783
- Views 69
- Downloads 0
CHOSEN ASPECTS OF LIFESTYLES OF PHYSICALLY ACTIVE WOMEN AGED 45-59 AND 60-74
Background. The aim of the study was to compare chosen aspects of lifestyle of women aged 45-59 and 60-74. Material and methods. The study, carried out between 2013 and 2015, embraced 120 women who engaged in physical ac...
THE REVIEW OF RESULTS OF RESEARCH ON BREASTFEEDING CONSIDERING MEDICINAL AND PROPHYLACTIC ASPECTS
Breastfeeding is an irreplaceable, in biological and emotional aspect, basis of mother and child’s health. The aim of this paper was to present the review of research results on advantages of natural feeding and benefits...
ISOBOLOGRAPHIC ASSESSMENT OF INTERACTIONS BETWEEN RETIGABINE AND PHENYTOIN IN THE MOUSE MAXIMAL ELECTROSHOCK-INDUCED SEIZURE MODEL AND CHIMNEY TEST
Background. Search for beneficial combinations of antiepileptic drugs (AEDs) that can be used in patients with pharmacoresistant epilepsy, is still conducted both empirically and rationally, based on molecular mechanisms...
HEALTH-PROMOTING EFFECTS OF MANUKA HONEY
Honey properties are determined by the level of methylglyoxal (antimicrobial substance) from 30 to 550 in the case of MGO method or from 5 to 20 by UMF method. Previous studies have shown that high levels of methylglyoxa...
THE PRESENCE OF INTERFERING ANTIBODIES IN SELECTED CONTROL SERA ON THE EXAMPLE OF A SET FOR DETERMINATION OF IPSA
The human sera often contain substances which interfere in the course of immunochemical reactions. lt is essential for the control sera used to determine concentrations of antigen of the prostate not to contain such ingr...