Pleomorphic T- cell Immunoblastic Non-Hogdkin’s Lymphoma with Peripheral Eosinophilia: A Case Report
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 1
Abstract
Hypereosinophilia is defined as peripheral blood eosinophil count > 1500/ l and is often seen associated with many hematolymphoid malignancies. The present case describes a 75 year old male who presented initially with eosinophilia and complaints related to allergic bronchitis and atopy. After a period of irregular follow – up (two years after his initial diagnosis) patient came in emergency with severe dyspnoea and cough. Chest X-Ray showed multiple hilar opacities with CT chest revealing mediastinal lymph nodes including cervical and supra-clavicular lymphadenopathy. Hematological findings were leucocytosis with hypereosinophilia. (Total leukocyte count-65,000/cumm, comprising of 80% eosinophils, 09% neutrophils and 11% lymphocytes). Fine needle aspiration done from various sites was suggestive of lymphoproliferative disorder. On histopathology; working diagnosis of NHL- Large cell type was rendered with IHC showing immunopositive for LCA(CD45)/CD3 /CD45RO, and immunonegative for CD7/ CD20. The Ki-67 index was 90%. Hence a final diagonosis of Pleomorphic T –cell Lymphoma High grade (Large Cell, Immunoblastic Lympoma of T-cell Type of WHO/REAL Working Formulation) was rendered. HES has two pathogenic forms – myeloproliferative and lymphocytic. Lymphocytic – HES which is associated with increased risk of developing a T-Cell lymphoma later on due to secretion of IL-5 by abnormal clonal T- cells. It is recommended in all the cases of long standing eosinophilia and HES patient to be kept under follow up for early detection of development of T-cell lymphoma.
Authors and Affiliations
Manisha Sharma, Rahul Mannan, Mohit Madhukar, Mridu Manjari, Jasmin Kaur Bawa
Keywords
Related Articles
- EP ID EP39778
- DOI -
- Views 315
- Downloads 0
Prevalence of Anemia Among Female Undergraduate Students of Government Medical College Kottayam, Kerala
Background: Anemia is a problem among young adult females. The present study was planned to estimate the prevalence and selected determinants of anemia among female undergraduates of Government Medical College Kottayam....
Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast : A Case Report
Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign proliferating messenchymal lesion of the breast. The common presentation of this lesion is usually an incidental microscopic foci & rarely they may...
Anti Thymocyte globulin therapy for treatment of Aplastic Anemia- A retrospective Study
Background: Anti thymocyte globulin therapy is considered as standard first line immunosuppressive therapy for patients with acquired aplastic anemia. Aim of this study is to evaluate the response of anti thymocyte glob...
Assessment of knowledge of Medical Students about Reproductive and Child Health Programme of India by Using Simple Intervention
Introduction: Understanding Reproductive and Child Health Programme (RCH) is necessary for medical students not only because it is a part of medical curriculum, but also training of medical as well as paramedical studen...
The study of auditory and visual reaction times in chronic smokers
Audio-visual reaction time is a reliable indicator to assess the processing capability of central nervous system and sensory motor performance in response to an external stimulus. The present study was aimed to find ou...