PlGF/sFlt‑1 as Early Detection Biomarker for Preeclampsia
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2017, Vol 6, Issue 2
Abstract
target, particularly improving maternal health and lowering maternal mortality until one-fourth of population from 1990 until 2015. Then, this program was continued through Sustainable Development Goals (SDGs) in 2015 with lowering maternal mortality below 70 per 100,000 live births and reducing premature mortality due to one-third because of uncommunicable diseases. Maternal mortality in Indonesia is quite high compared with the other countries in the Southeast Asia. Generally, the main causes of maternal death are haemorrhage (28%), preeclampsia (PE)/eclampsia (24%), infection (11%), complications from birth delivery (5%), and unsafe abortion (5%). Preeclampsia (PE) is a hypertension disease accompanied with proteinuria that occuring in 20 weeks of pregnancy (second trimester). The disease is commonly unvisible and underdiagnosed until clinical manifestations were presented (e.g. maternal and fetal disorders). However, it can lead to maternal death during childbirth if this problem not addressed seriously. It was reported that the average incidence of PE reached 2–10% worldwide. Various efforts have been undertaken to lowering maternal mortality that is early detection of PE. The purpose of this review was to analyze the most effective early detection method to overcome PE based on literaure review. The methods of this review were data-based searching based on Pubmed, Scopus and Google Scholar, without limitation of index factor by using the keyword “biomarkers, preeclampsia”, “early detection, preeclampsia.” The results of the review showed that placental growth factor biomarkers (PlGF) and soluble Fms-like tyrosine kinase 1 (sFlt-1) is the specific biomarkers with high sensitivity and specificity in detection of PE.
Authors and Affiliations
Rano K. Sinuraya, Hidayatun Nisa, Trifena Lokajaya, Tri N. S. Puri
Keywords
Related Articles
- EP ID EP369703
- DOI 10.15416/ijcp.2017.6.2.123
- Views 84
- Downloads 0
Impact of Pharmaceutical Home Care on Compliances and Clinical Outcomes of Hypertensive Patients
In the Indonesian health universal coverage system the hypertensive patients that grouped into the refer back patient treatment category, is one target of pharmaceutical home care. The aim of this study was to carried ou...
PlGF/sFlt‑1 as Early Detection Biomarker for Preeclampsia
target, particularly improving maternal health and lowering maternal mortality until one-fourth of population from 1990 until 2015. Then, this program was continued through Sustainable Development Goals (SDGs) in 2015 wi...
Relationship Between Compliance of Using β2-Agonist Inhaler Drug and Asthma Control on Asthma Patient
Asthma remains a health problem affecting a large number of children and adult in the world. Being a chronic disease, asthma management requires continous medications. One of the most important issues in asthma managemen...
A Prospective Study of Adverse Drug Reactions in 1 Month–12 Years Old Pediatric Patients
Adequate controlled clinical trials in pediatric population, especially in oncology and vaccinations are still insufficient due to ethical considerations. Certain conditions in children in general and in Indian children...
Association between Perceived Value and Self-Medication with Antibiotics: An Observational Study Based on Health Belief Model Theory
High prevalence of self medication with antibiotics can increase the probability of irrational use of antibiotics which may lead antibiotics resistance. Thus, shifting of behavior is required to minimize the irrational u...