Pocket-Based Drug Design: Exploring Pocket Space
Journal Title: The AAPS Journal - Year 2013, Vol 15, Issue 1
Abstract
The online version of this article (doi:10.1208/s12248-012-9426-6) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Xiliang Zheng, LinFeng Gan, Erkang Wang, Jin Wang
Keywords
Related Articles
- EP ID EP681771
- DOI 10.1208/s12248-012-9426-6
- Views 72
- Downloads 0
Population Pharmacokinetics and Exposure-Uric Acid Analyses After Single and Multiple Doses of ABT-639, a Calcium Channel Blocker, in Healthy Volunteers
ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain. In the current first-in-human (FIH) study, the pharmacokinetics, tolerability...
Population-Based Efficacy Modeling of Omalizumab in Patients with Severe Allergic Asthma Inadequately Controlled with Standard Therapy
The online version of this article (doi:10.1208/s12248-013-9463-9) contains supplementary material, which is available to authorized users.
An Update of the Brazilian Regulatory Bioequivalence Recommendations for Approval of Generic Topical Dermatological Drug Products
This note aims to clarify the Brazilian regulatory bioequivalence recommendations for approval of generic topical dermatological drug products, since the legal framework of the “Brazilian Health Surveillance Agen...
Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration
The online version of this article (doi:10.1208/s12248-015-9782-0) contains supplementary material, which is available to authorized users.
The Utility of Modeling and Simulation Approaches to Evaluate Immunogenicity Effect on the Therapeutic Protein Pharmacokinetics
While therapeutic proteins (TP), particularly recombinant human proteins and fully human monoclonal antibodies, are designed to have a low immunogenic potential in humans, a clinical immune response does sometimes occur...