Poly (ADP-Ribose) Polymerase Immunoexpression as Chemoresistance Marker in Ovarian Carcinoma
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2018, Vol 7, Issue 2
Abstract
Epithelial ovarian cancer (EOC) is the fifth most common cancer and the main cause of gynecological cancer death worldwide. Chemotherapy is the main therapy in advanced stage of EOC. Poly (ADPRibose) Polymerase (PARP) dan B cell Lymphoma-2 (Bcl-2) are immunohistochemistry markers that represent influential factors in chemotherapy response which have roles in DNA repair and antiapoptosis. The aim of this study was to review the correlation between PARP and Bcl-2 expression with chemotherapy response in EOC. This research was performed as analytic-observational with cross-sectional design using paraffin block of patients diagnosed as EOC in 2012–2015 at Anatomical Pathology Department, Hasan Sadikin Hospital Bandung. Total sample was 58 cases which were divided into chemotherapy sensitive and resistant. All samples were stained by immunohistochemistry PARP and Bcl-2 and analysed using Chi-Square test with significant level of 5%. The results of this study showed that 60% of all samples have strong PARP expression whereas the largest proportion is in chemotherapy resistant group (p=0.001) and 74% of all samples have weak Bcl-2 expression in each group (p=0.45). The conclusion of this study in chemotherapy response was influenced by PARP. Higher PARP immunoexpression showed higher tumour cell ability to repair DNA and higher chemotherapy resistance.
Authors and Affiliations
Retno Westiningrum, Hermin A. Usman, Herry Yulianti, Bethy S. Hernowo
Keywords
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- EP ID EP370286
- DOI 10.15416/ijcp.2018.7.2.115
- Views 107
- Downloads 0
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