Polymeric Matrices at Micro and Nanoscale for Ocular Drug Delivery
Journal Title: Saudi Journal of Biomedical Research - Year 2017, Vol 2, Issue 4
Abstract
Abstract: Drug delivery platforms have the potential to improve patient adherence, reduce side effects, increase efficacy for treatment of ocular diseases. Recent efforts in ocular drug delivery have been made to improve the bioavailability and precorneal residence through topical application. The potential use of polymeric micro and nanoparticles as drug carriers has led to the development of many advanced colloidal delivery vehicles. Drug loaded polymeric systems offer several favorable biological properties, such as biodegradability, nontoxicity, biocompatibility and mucoadhesive characteristics. These polymeric systems are amenable for targeted drug delivery, leading to decrease in dose, dosing frequency and thus lowering systemic toxicity. This review discusses the recent advances in polymeric micro and nanoparticles and their therapeutic significances in the field of ocular drug delivery. Keywords: Drug delivery, ocular diseases, topical application, mucoadhesive.
Authors and Affiliations
Narendar Reddy Doodipala
Keywords
Related Articles
- EP ID EP387286
- DOI -
- Views 81
- Downloads 0
Comparative Study of Antioxidant Activity and Hepato-Protective Effect of Extracts of Tetracarpidiumconophorumand Dacryodesedulison Sodium Arsenate Exposed Rats
Abstract:This study comparatively evaluated the in vitro antioxidant activity and the hepato-protective effect of extracts of two locally consumed fruits, Dacryodesedulis(African pear) and Tetracarpidiumconophorum (Afric...
Identification and immune recognition of viral epitopes of West Nile Virus envelope glycoprotein and their potentials of acting as peptide vaccine
Abstract: West Nile virus (WNV) is a small, enveloped, mosquito transmitted virus with a positive sense, 11 kb RNA genome. It was first isolated in 1937 from a woman with an undiagnosed febrile illness in the West Nile d...
Evaluation of Extract Fractions of Vernonia calvaona on Some Biochemical Parameters and Histopathological Changes in Albino Wistar Rats Exposed To Domestic Insecticides
Abstract:Despite widespread use, little is known about the risk associated with insecticides exposure to human health hence, this study. 48 wistar rats (90-120g) were randomly grouped into six (n=8). All except Normal co...
Transition metal oxides nanoparticles catalysis for sustainable organic synthesis under solvent free conditions
Abstract: Organic reactions are typically carried out in the presence of solvents. Isolation of the pure products requires separation and purification steps, which result in a substantial decrease in yield and can be env...
What is the Novel Delivery System Used for Oral Bioavailability Enhancement of Poorly Water Soluble Drugs?
Abstract:Majority of the drugs used for the treatment of various diseases are administered by oral route using conventional delivery. The major drawback of the oral administration is the poor bioavailability due to the p...