Polymeric Nanocarriers for Transport Modulation across the Pulmonary Epithelium: Dendrimers, Polymeric Nanoparticles, and their Nanoblends
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-014-9588-5) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Balaji Bharatwaj, Radovan Dimovski, Denise S. Conti, Sandro R. P. da Rocha
Empirical and Semi-Mechanistic Modelling of Double-Peaked Pharmacokinetic Profile Phenomenon Due to Gastric Emptying
Models have been developed to explain double-peaked plasma concentration-time profiles using mechanisms such as variable absorption and enterohepatic recirculation. Interruption of gastric emptying has also been shown to...
Similar Intracellular Peptide Profile of TAP1/β2 Microglobulin Double-Knockout Mice and C57BL/6 Wild-Type Mice as Revealed by Peptidomic Analysis
The online version of this article (doi:10.1208/s12248-010-9224-y) contains supplementary material, which is available to authorized users.
Fetal Microchimerism in Cancer Protection and Promotion: Current Understanding in Dogs and the Implications for Human Health
Fetal microchimerism is the co-existence of small numbers of cells from genetically distinct individuals living within a mother’s body following pregnancy. During pregnancy, bi-directional exchange of cells occur...
Exposure-response relationships and drug interactions of sirolimus
Sirolimus (rapamycin, RAPAMUNE, RAPA) is an immunosuppressive agent used for the prophylaxis of renal allograft rejection and exhibits an immunosuppressive mechanism that is distinct from that for cyclosporine and tacrol...
Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery
Metabolism-related liabilities continue to be a major cause of attrition for drug candidates in clinical development. Such problems may arise from the bioactivation of the parent compound to a reactive metabolite capable...