Polymorphism in coding and regulatory sequences of beta-casein gene is associated with milk production traits in Holstein-Friesian cattle
Journal Title: Animal Science Papers and Reports - Year 2012, Vol 30, Issue 1
Abstract
Beta-casein gene (CSN2) is considered a marker of milk production traits in dairy cattle. Allele A2, the most common in Holstein-Friesian breed, is beneficial for milk protein yield. However, within CSN2 other mutations occur which could potentially be involved in shaping the variation of milk production traits. In this study a new SNP (C/T) was found located within a regulatory sequence of CSN2 (position -1578), called enhancer which is thought to play an important role in the amount of the beta-casein mRNA produced. The aim of the study was to verify effects of both SNPs on milk production traits in Polish Holstein-Friesian (HF) dairy cattle. Six-hundred-and-fifty bulls were genotyped with two methods, PCR-ACRS (Amplification-Created Restriction Site, Mph1103 I) and PCR-RFLP (EcoR I), for the A1/A2 polymorphism and the C/T SNP polymorphism (BCE129), respectively. Although both SNPs are located close to each other, their allele frequencies were found significantly different (0.33, 0.67, 0.89 and 0.11 for the A1, A2, C and T, respectively). A mixed linear model was used for testing the association between these polymorphisms and deregressed breeding values for production traits. The analysis revealed that the allele coding the A2 protein variant increases breeding values for milk and milk protein yields while allele C of BCE129 increases the milk fat yield.
Authors and Affiliations
Kamil Oleński, Anna Cieślińska, Tomasz Suchocki, Joanna Szyda, Stanisław Kamiński
Keywords
Related Articles
- EP ID EP70717
- DOI -
- Views 142
- Downloads 0
The impact of heat treatment methods on the physical properties and cooking yield of selected muscles from Limousine breed cattle
The aim of this study was to analyse the impact of heat treatment methods (frying – FR, grilling – GR, roasting – RO 180°C, roasting – RO ΔT) on certain physical properties and the cooking yield of selected muscles of ca...
QTL in chicken: a look back and forward − a review
Identification of genes determining the expression of economically important traits of plants and animals is a main research focus in agricultural genomics. Most of these traits are characterized by a wide variability of...
Traits of drug and explosives detection in dogs of two breeds as evaluated by their handlers and trainers
Police dogs handlers’ and trainers’ opinions on Labrador retrievers (n=87) and German shepherds (n=96) trained for drugs vs. explosives detection have been compared. As most important traits in both specialties the respo...
Polymorphism in exon 2 of INHBB gene and its relationship with litter size in Jining Grey goats
The inhibin βB(INHBB) gene was studied as a candidate gene for the prolificacy of Jining Grey goats. According to the sequence of bovine INHBB gene, two pairs of primers were designed to detect single nucleotide polymorp...
Five novel SNPs of the bovine LHX4 gene and their association with growth traits in native Chinese cattle breeds
LHX4 is a LIM homeodomain transcription factor involved in pituitary ontogenesis. Some mutations of LHX4 are associated with combined pituitary hormone deficiency that affects growth and development in animal. The object...