Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass.
Journal Title: Journal of Clinical Endocrinology and Metabolism - Year 2004, Vol 89, Issue 10
Abstract
Epidemiological studies point to the importance of gene-environment interactionsduring early life as determinants of later osteoporosis and fracture. We examined associations betweencommon single nucleotide polymorphisms in the human GH (GH1) gene and weight in infancy, adult bone massand bone loss rates, and circulating GH profiles. Two hundred and five men and 132 women, aged 61-73yr, in the Hertfordshire Cohort Study were included; bone mineral density was measured by dual energyx-ray absorptiometry over 4 yr. Twenty-four-hour circulating GH profiles were constructed in a subsetof 71 men and women. Genomic DNA was examined for two single nucleotide polymorphisms in the GH gene(one in the promoter region and one in intron 4). Homozygotes at loci GH1 A5157G and T6331A displayedlow baseline bone density and accelerated bone loss; there was also a significant (P = 0.04) interactionamong weight at 1 yr, GH1 genotype, and bone loss rate. There was a graded association between allelesand circulating GH concentration among men. This study suggests that common diversity in the GH1 regionpredisposes to osteoporosis via effects on the level of GH expression. The interaction with infant weightsuggests that early environment may influence the effect of GH1 genotype on bone loss.
Authors and Affiliations
H E Syddall, S Rodriguez, E M Dennison, A Voropanov, I N M Day, C Cooper
Keywords
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