POLYMORPHISM OF THE α-ACTN3 GENE IN INDIVIDUALS PRACTISING DIFFERENT SPORTS DISCIPLINES
Journal Title: Biology of Sport - Year 2011, Vol 28, Issue 2
Abstract
In this study the R577X polymorphism of the α-actinin-3 (ACTN3) gene was analysed in relation to physical fitness measured with maximal oxygen uptake (VO2max). The studies were carried out in a group of 154 men and 85 women, students of the University of Physical Education in Poznań and professional athletes representing various sports and fitness levels. In our research physiological and molecular procedures were used, i.e. direct measurement of maximum oxygen uptake (VO2max) and R577X a-ACTN3 genotyping by PCR-RFLP. The results do not confirm some literature data concerning a statistically significant association of R577X polymorphism in the ACTN3 gene and the level of maximal oxygen uptake (VO2max). A trend was observed for higher VO2max values to be found in individuals with the XX and RX genotypes as well as the predominance of the RR genotype in the group of individuals practising speed and power disciplines.
Authors and Affiliations
J Holdys, D Stanisławski, P Gronek
Keywords
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