Polymorphisms of HLA Class I and II Alleles in Iraqi Patients with Hepatic Hydatid Infection
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 4
Abstract
Background: Hepatic hydatid disease (HHD) is a parasitic zoonosis caused by larval stage of Echinococcus tape worm. In addition to environmental factors, genetic constitution of hosts seems to play a crucial role in acquiring the infection and developing disease. Aims: This study was carried out to investigate the association of HLA-class I and class II (A, B, DR and DQ) alleles with HHD by genotyping in Iraqi patients, as well as to provide information about genotypes that confer susceptibility or resistance to develop the disease. Materials and Methods: Twenty patients with HHD, their age range (20-50) years and 20 healthy controls their ages were matched with the patients were enrolled in this study. Blood was collected from patients and controls, DNA was extracted from blood samples, and then HLA-class I and class II genotyping was performed by polymerase chain reaction-sequence specifc oligonucleotide probes (PCR-SSO). Results: The present fndings showed that frequencies of HLA-A*32 (65%; P=0.011), DRB1*11 (60%; P=0.004) and DQB1*03 (70%; P=0.007) alleles are signifcantly higher in patients than controls, while the frequency of DRB1*04 was signifcantly decreased in patients when compared to controls (25% vs. 75%; P=0.002). Furthermore, the current study could not observe signifcant differences in the frequencies of HLA-B alleles between patients and controls. Conclusions: We concluded that HLA-A*32, DRB1*11 and DQB1*03 alleles might contribute to the increased susceptibility to HHD and DRB1*04 could be a protective marker against the disease.
Authors and Affiliations
Al-Ghurabi Batool H| Department of Basic Science, College of Dentistry, University of Baghdad, Iraq, Corresponding e-mail: batoolamms@yahoo.com, Raheem Samir S| Department of Biology, College of Science, Al-Muthana University, Iraq, Al-Taie Lazim H| Department of Clinical Laboratory Science, Pharmacy College, Al-Nahrain University, Iraq, Abbas Ahmed A| Department of Microbiology, Medical College, Al-Nahrain University, Iraq
Keywords
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