Positive Anti-Cadmium Poisoning Anti-Oxidant Effects of Moringa Seed Oil and Cashew Nut Oil in Juvenile Wistar Rats Hippocampus
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 5, Issue 1
Abstract
Moringa oleifera seed oil and Anacardium occidentale oil contain certain antioxidants including ascorbic acid, phenolics, flavonoids and carotenoids; these antioxidants have potentials to act against oxidative stress generated by cadmium accumulation and activities in tissues. This study was aimed at investigating some antioxidant effects of moringa seed oil and cashew nut oil on cadmium toxic effects in the hippocampus of Wistar rats. Thirty five juvenile male Wistar rats were divided into seven groups (A, B, C, D, E, F and G) of five (5) animals. Group A served as control [fed ad libitum]; Groups B, C, D, E, F and G were injected intraperitoneally with 2.5 mg/kg of cadmium sulphate (3CdSO4.8H2O) to induce cadmium poisoning. After cadmium administration: Group B animals were left untreated; Group C and D animals received daily oral administration of 100 mg/kg vitamin C and 30 mg/kg vitamin E respectively; Groups E and F were administered 4 mg/kg of Moringa seed oil and 4 mg/kg of Cashew nut oil respectively- orally and daily, while Group G received daily oral administration of 2 mg/kg of Moringa oleifera oil and 2 mg/kg of Cashew nut oil [combined]. The experiment lasted three weeks [21 days]; animals were sacrificed and the hippocampus and blood were assayed for enzymes LDH, G6PDH, SOD and GPx. Average weights and blood sugar were also measured. Results indicate that cadmium caused oxidative stress in the hippocampus by upsetting the tested enzymes’ activities significantly; these effects were ameliorated by the anti-oxidant contents of the oils to varying extents.
Authors and Affiliations
O. D. Omotoso, J. O. Owolabi, H. B. Akpan, B. J. Dare, E. A. Ashamu, S. A. Adelakun
Keywords
Related Articles
- EP ID EP328434
- DOI 10.9734/JAMPS/2016/16310
- Views 91
- Downloads 0
Oxytocin Hormone Administration Attenuates Cardiac Oxidative Injury and Inflammation in Hypercholesterolemic Rats
Aims: Oxytocin (OT) hormone has been recently recognized as a cardiovascular hormone with diverse regulatory roles. The present study examined the potential protective effect of exogenous OT administration on hypercholes...
Mucous Retention Cyst – Review of Literature and a Case Report
Mucocele is a mucin filled cavity and is one of the most common salivary gland pathology. It arises either due to severance of a duct or due to an obstruction to the salivary flow. In the former case, the more appropriat...
Antibacterial Activity and Phytochemical Screening of Mangifera indica (Mango) Stem and Leaf Extracts on Clinical Isolates of Methicillin Resistant Staphylococcus aureus
Background: Medicinal plants have been sources of a number of important compounds which have been discovered during last century. In the light of their established therapeutic efficacy, the pharmaceutical industries are...
Evaluation of the Physicochemical Properties and Quality Indices of Multisource Tadalafil Drug Products Marketed in Nigeria
The present study evaluates and compares the physicochemical parameters and cost of some multisource tadalafil products marketed in Nigeria. Six randomly selected products were analyzed for weight uniformity, friability,...
Induction of Heme Oxygenase-1 Improves Glucose Tolerance and Enhances Insulin Sensitivity in Obese Diabetic Rats
Aims: Obesity is a worldwide problem. It is considered to be a major risk factor for many systemic diseases like type 2 diabetes mellitus (T2D), cardiovascular, renal and orthopedic diseases. Recent evidence has undersco...