Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
The aim of this study was to evaluate the changes in testicular function of rats due to cigarette smoke exposure and the possible mechanism by which zinc protects against these alterations.
Authors and Affiliations
Michele Sankako, Patricia Garcia, Renata Piffer, Bruna Dallaqua, Dębora Damasceno, Oduvaldo Pereira
Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.
This review briefly summarizes the information on the molecular mechanisms of action, pharmacokinetic profiles and drug interactions of novel (third-generation) antiepileptic drugs, including brivaracetam, carabersat, ca...
Effect of metyrapone on the fluoxetine-induced change in extracellular dopamine, serotonin and their metabolites in the rat frontal cortex.
Major depression is frequently associated with the hyperactivity of the hypothalamic-pituitary-adrenocortical axis, and glucocorticoid synthesis inhibitors have been shown to exert antidepressant action. Metyrapone (an i...
Effects of valproic acid (VPA) and levetiracetam (LEV) on proliferation, apoptosis and hormone secretion of the human choriocarcinoma BeWo cell line.
Epilepsy has been associated with poor obstetric outcomes that may be the result of the epilepsy or a direct effect of anti-epileptic drugs on placentation. To investigate any direct effect of anti-epileptic drugs on cel...
Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs.
Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study was to evaluate the effects of terfenadine, ketoconazole...
Effects of etoricoxib on the pharmacokinetics of phenytoin.
Etoricoxib is presently the most commonly prescribed cyclooxygenase-2 (Cox-2) inhibitor for chronic pain and inflammatory conditions. In clinical practice, phenytoin and etoricoxib are used in chronic conditions of gener...