Possible Protective Effect of Pumpkin Seed Oil against Sodium Nitrite in Rats; A Biochemical and Genetic Study
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2017, Vol 6, Issue 2
Abstract
Objective: The aim of our study was to test the protective effect of pumpkin seed oil against sodium nitrite toxicity in rats. Methods: Forty eight adult male albino rats were divided into 4 groups. The rats were administered daily 100 mg/kg/day sodium nitrite in presence/absence of 1.5 ml/kg/day pumpkin seed oil for 5 weeks. Results: The results indicated that sodium nitrite induced oxidative stress, lipids profile disorders, DNA damage and chromosomal abnormalities. The pumpkin seed oil has antioxidant effect; it improved levels of total antioxidant capacity, malondialdehyde and lipids profile. It also has antimutagenic effect; it decreased the DNA damage and structural chromosomal abnormalities. Conclusion: Pumpkin seed oil can ameliorate the toxic effects induced by sodium nitrite.
Authors and Affiliations
Walaa Yehia Abdelzaher
Keywords
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- EP ID EP324184
- DOI 10.19070/2167-910X-1700044
- Views 65
- Downloads 0
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