Possible Role of Inadequate Quantities of Intra-Thyroidal Bromine, Calcium and Magnesium in the Etiology of Female Subclinical Hypothyroidism
Journal Title: Interventions in Gynaecology and Women’s Healthcare - Year 2018, Vol 1, Issue 3
Abstract
Objective: Subclinical hypothyroidism does affect fertility. The prevalence of subclinical hypothyroidism is 10-15 times more common in women than in men. Many chemical elements play important role in thyroid function and fertility. The aim of this exploratory study was to evaluate whether significant differences of chemical element contents exist between female and male thyroids and how they can be related to the etiology of subclinical hypothyroidism. Methods: Thyroid tissue levels of Br, Ca, Cl, I, K, Mg, Mn, and Na were prospectively evaluated in 105 healthy persons (33 females and 72 males). Tissue samples were used for chemical element measurements, employing instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Results: It was found that the Br thyroid content of females was significantly higher than that of males, while the Ca and Mg contents were lower. Conclusion: Inappropriate content of intra-thyroidal Br, Ca and Mg can be associated with the etiology of female subclinical hypothyroidism.Adequate thyroid function is important to maintain normal reproduction, because thyroid dysfunction affects fertility in various ways resulting in abnormal ovulatory cycles, luteal phase defects, high prolactin levels, and sex hormone imbalances [1,2]. Therefore, normal thyroid function is necessary for fertility, and to sustain a healthy pregnancy [2]. From large population studies, which measured thyroid function, and systematic reviews of this subject carried out in the 1990s to 2010s, it is known that untreated hypothyroidism is a common condition all over the world [2-11]. The prevalence of subclinical hypothyroidism (SCH) is between 1% and 10% in different countries [2-11] and almost everywhere it is 10-15 times more common in women than in men [4,10]. Form such a great gender-related difference in the prevalence of SCH arises a question about a specific sensitivity of female thyroid tissue to some external and internal factors.
Authors and Affiliations
Zaichick Vladimir
Keywords
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- EP ID EP569606
- DOI 10.32474/IGWHC.2018.01.000113
- Views 93
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