POSSIBLE ROLE OF SODIUM CROMOGLYCATE, A MAST CELL STABILIZER IN HALTING GENTAMICIN NEPHROTOXICITY IN RATS. Neha Machhan
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2017, Vol 5, Issue 1
Abstract
Gentamicin is commonly used in treating life threatening gram-negative bacterial infections, butmajor limitation is its nephrotoxic effect. Free radical generation and reduction in antioxidantdefense mechanisms are mainly considered to be involved in gentamicin induced nephrotoxicity,but the exact mechanism still remains unclear. Mast cells are infiltrated in the inflamed kidneyand their degranulation releases various inflammatory mediators during various renal diseases.We have investigated the possible involvement of mast cell stabilizer sodium cromoglycate[SCG] in halting gentamicinnephrotoxicity in rats. Administration of gentamicin [GM] 100mg/kg i.p. for 10 days in rats induced nephrotoxicity, characterized by significantly [P<0.05]increased serum creatinine, blood urea nitrogen, urinary protein, renal oxidative stress and mastcell density, decreased creatinine clearance and histopathological alterations. Co-administrationof SCG [24mg/kg/day] attenuated significantly [P<0.05], all these biochemical parameters,reduced mast cell density and prevented the histological alteration such as intracellular edema,glomerulus narrowing and necrosis in epithelial cells of the proximal tubules. It is concluded thatmast cells have a detrimental role in gentamicin-induced nephrotoxicity and SCG stabilizes mastcells, reduces the release of various proinflammatory cytokines and thus, prevents the toxiceffects of GM as seen in both, the biochemical and histopathological parameters.
Authors and Affiliations
Neha Machhan
Keywords
Related Articles
- EP ID EP303022
- DOI -
- Views 114
- Downloads 0
ANTI FERTILITY ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRILLIUM GOVANIANUM IN ETHINYL ESTRADIOL INDUCED ANTI FERTILITY MODEL IN RATS
Lack of fertility is in fertility were as anti-fertility is to reduce fertility. Fertility is burning issue of global as well as national public issue which are concerning the fast growth of the country. Increase rate of...
NIPAH VIRUS –THREAD TO PREGNANCY
Nipah virus is a type of zoonotic virus. Which cause serious respiratory nervous problems along with serious fever it get easily transmitted to one infected person to another person. Nipah virus is a great thread to mank...
EBOLA VIRUS: AN OVERVIEW
Ebola virus disease (EVD), also known as Ebola hemorrhagic fever (EHF) or simply Ebola, is a viral hemorrhagic fever of humans and other primates caused by ebola viruses. Signs and symptoms typically start between two da...
REGULATORY PERSPECTIVE OF BIOSIMILARS IN INDIA
Biosimilar drugs are follow-on versions of original biopharmaceutical medicines. They are independently developed after the patent protecting the original product has expired. Biosimilars are designed to target specific...
KNOWLEDGE AND PRESCRIBING PRACTICE OF AMBULATORY CARE PHYSICIANS ABOUT DISTINCT ANTIBIOTICS TOWARDS TRIVIAL RESPIRATORY TRACT INFECTED PATIENTS: STRATEGIES FOR OPTIMAL OUTCOMES AND MINIMIZED RESISTANCE
According to World Health Organization (WHO), respiratory tract infections kill 2.6 million children every year worldwide so, it is recognized as the leading cause of morbidity and mortality. Respiratory tract diseases a...