Post Transplant Lymphoproliferative Disorder of The Renal Allograft : A Case Report

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Post Transplant Lymphoproliferative Disorder of The Renal Allograft : A Case Report

Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 5

Abstract

Patients receiving a solid organ transplant have an increased risk of developing Post Transplant Lymphoproliferative disorder (PTLD). Incidence of PTLD is 1% in renal allograft recipients. Most of the PTLDs are of B cell origin, and are found to have evidence of Epstein–Barr virus (EBV) infection. The immunosuppressant mediated decrease in activity of the natural cytotoxic T-cells is probably one of the contributing factors. We report a case of PTLD occurring in the transplanted kidney of a 45 year old male, 7 years after transplant who presented with graft dysfunction. The graft biopsy revealed presence of lymphoid proliferation, confirmed by histochemistry and a diagnosis of monomorphic B-cell lymphoma was made. He was treated by reducing the immunosuppression and is doing well on follow up.

Authors and Affiliations

Kathulapali Krishna, Varun Kumar B. , Ram Prasad E. , Soudararajan P.

Keywords

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EP ID EP562196
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