Postagressional Arterial Remodeling: An Experimental Study
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 7
Abstract
AIM: The unprecedented development of cardiac surgery and interventional cardiology we have witnessed these past years, has led to an increassing need to find solutions for the post-traumatic modifications of the arterial wall: stenosis and neointimal proliferation. The aim od this study is to asses the effect of diltiazem on reactive prolifferation of the intima after lesion in an experimental model (rabbit) and to quantify these modiffications from a qualitative and quantitavive point of view. MEANS AND METHOD: We used 20 male rabbits, weighing between 2,5-3kg, to which a lesions was made using the baloon of a Fogarty catheter on the left internal carotid artery. The lot was dividen into two groups: one group (A) to which we only administered fractioned heparin post-operatively, the other group (B) to which we administered 3g of diltiazem two times a day in addition to fractioned heparin. The subjects were examined clinicaly and with doppler ultrasound 24h, 7days, 14 days and 30 days after surgery. Upon sacrification, the carotid artery was examined under optical microscopy. RESULTS: The site of the lesions induced were mainly on the intimal level as follows: mural hematoma, clivation of the supperficial layer or intimo-medial dilaceration. On succesive sections one can asses intimal prolifferation, with either concentrical of excentrical disposition, the healing the the lesions with a tendency to oclusion in deep lesions. CONCLUSION: Intimal hiperplasia appears as a healing reaction after a surgicaly induced intimal lesion. Diltiazem appears to inhibit intimal proliferration.
Authors and Affiliations
MOLNAR ADRIAN, * TRIFAN CATALIN
Keywords
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