Posterior leukoencephalopathy syndrome in patients on cyclosporine A treatment following allogeneic hematopoietic stem cell transplantation
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 1
Abstract
Cyclosporine A is widely used as therapeutic agent for immunosuppressive treatment after allogeneic stem cell transplantation. Although several neurotoxic side effects are known the pathogenesis of the involvement of central nervous system remains not fully understood [-,,]. Various clinical manifestations of cyclosporine A toxicity exist with tremor, seizures, neuropathy, visual disturbances or cerebellar ataxia. A reversible posterior leukoencephalopathy syndrome with altered consciousness, seizures, cortical blindness, headache associated with MRI findings of bilateral subcortical and cortical edema with a predominantly posterior distribution is rare but the most serious complication [,]. We report four patients (age 25 – 54 years) who developed a fluctuating psychoorganic syndrome with altered consciousness, disorientation, headache, visual disturbances and seizures under immunosuppressive therapy with cyclosporine A.
Authors and Affiliations
Peter GUNTHER, Wieland HERMANN
Keywords
Related Articles
- EP ID EP82803
- DOI -
- Views 96
- Downloads 0
Proximal Conduction Time Along The Lumbar Plexus
Scientific Background: One of the matters in clinical neurophysiology is evaluation of the proximal conduction time along the lumbar plexus. Objectives: Instead of investigating only distal segment of the nerve from the...
Does Irrigation System (Pulsavactmplus) Lead to Intravascular Passage of Irrigation Fluid During Major Spine Surgery?
Aim of this study is to evaluate the passage of irrigation fluid during irrigation with (Pulsavactmplus) and its effect on whole blood count and blood electrolytes level. After propofol, remifentanil and vecuronium induc...
The Effects of Paclitaxel on Nerve Conduction Velocity and Motor Unit Action Potential In Spraque-Dawley Rats
This study aimed to investigate the toxic effects of paclitaxel on sensory and motor nerve conduction velocities (SNCV and MNCV) and motor unite action potentials (MUAP) in adult male Spraque-Dawley rats. Rats were divid...
Oruç Sonrası Gelişen Serebral Venöz Sinüs Trombozu: Olgu Sunumu
Serebral venöz sinus trombozu, nadir rastlanan süregen ve tedaviye dirançli başağrılarında ayırıcı tanıda düşünülmesi gereken bir durumdur. 62 yaşında erkek hasta 3 günlük oruç sonrası başağrısı şikayeti ile başvurmuş, n...
Nöron ve Astrositleri Boyama İçin Doğal Boya
Giriş: Halı, yün ve pamuk boyaması için doğal boyalar kullanılır. Doğal boyalar aynı zamanda histolojik boyama amaçlı olarak da kullanılabilirler. Örnek olarak nar (Punica Granatum L. )ın kösele gibi sert kabuğunun boyam...