Posterior leukoencephalopathy syndrome in patients on cyclosporine A treatment following allogeneic hematopoietic stem cell transplantation
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 1
Abstract
Cyclosporine A is widely used as therapeutic agent for immunosuppressive treatment after allogeneic stem cell transplantation. Although several neurotoxic side effects are known the pathogenesis of the involvement of central nervous system remains not fully understood [-,,]. Various clinical manifestations of cyclosporine A toxicity exist with tremor, seizures, neuropathy, visual disturbances or cerebellar ataxia. A reversible posterior leukoencephalopathy syndrome with altered consciousness, seizures, cortical blindness, headache associated with MRI findings of bilateral subcortical and cortical edema with a predominantly posterior distribution is rare but the most serious complication [,]. We report four patients (age 25 – 54 years) who developed a fluctuating psychoorganic syndrome with altered consciousness, disorientation, headache, visual disturbances and seizures under immunosuppressive therapy with cyclosporine A.
Authors and Affiliations
Peter GUNTHER, Wieland HERMANN
Keywords
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