Postprandial Dyslipidemia as a Screening Tool for Risk Stratification of Acute Coronary Syndrome in Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Background: Type 2 Diabetes Mellitus is associated with the development of premature atherosclerosis. Deficiency of insulin and insulin resistance influences important enzymes and pathways in lipid metabolism. Diabetic dyslipidemia plays an important role in the pathogenesis of accelerated atherosclerosis. Methods: A total of 100 Type 2 Diabetes Mellitus (DM) patients who presented as in-patients with Acute coronary syndrome (ACS) were taken as cases and 50 controls with no diabetes mellitus were included. Lipid profile, fasting and postprandial was done for this study. Results: Our study shows statistically significant difference between cases and controls lipid profile in fasting and postprandial state. Lipid profile showed significant postprandial elevation of triglycerides(TGs), Very low density lipoproteins(VLDL) and decrease in High density lipoproteins(HDL) in cases. Conclusion: Postprandial lipid profile especially 4hours after normal meals may be an ideal evaluation tool to look for Coronary artery disease (CAD) risk in DM. Previously TGs have been suggested but our study also shows significant changes even in HDL and VLDL. Hence, including postprandial lipid profile in DM patients is a better predictor for risk stratification of Myocardial infarction and also to decide appropriate initiation of statin therapy.
Authors and Affiliations
Dr. Karthik Andela, Dr. R. Lakshmi Visruja2*, Dr. Y. J. V Reddy3, Dr. Srinivasa Rao4
Keywords
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- EP ID EP363341
- DOI 10.9790/0853-1702101620
- Views 47
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