Potential Involvement of Mitochondrial Dysfunction in Major Depressive Disorder: Recent Evidence
Journal Title: Archives of Depression and Anxiety - Year 2015, Vol 1, Issue 1
Abstract
Major depressive disorder (MDD) is a leading cause of morbidity and mortality, and it is a common psychological disorder in the world. Present antidepressants modulate monoamine systems directly or indirectly, because MDD is classically considered as a neurochemical disease, in which monoamine systems are perturbed including serotonin, noradrenaline or dopamine systems. However, recent evidences suggest that MDD is associated with the impairments of synaptic plasticity or cellular resilience to stress. Cellular resilience is maintained by mitochondria with the supplying cellular fuel or ATP. In addition, it is suggested that mitochondrial functions in neurons influence synaptic plasticity. Therefore, impairment of mitochondrial function can be the cause of the MDD. The present review article summarizes the recent evidences about the association between mitochondrial impairment and MDD, and it suggests that improvement of mitochondrial function become a potential drug target for MDD.
Authors and Affiliations
Kambe Yuki, Miyata Atsuro
Keywords
Related Articles
- EP ID EP334222
- DOI 10.17352/2455-5460.000004
- Views 94
- Downloads 0
Compulsive Bowel Emptying and Rectal Prolapse in Eating Disorders. Presentation of Two Cases
Eating Disorders are a heterogeneous group of complex psychiatric disorders that affect physical and psychological functioning, thus compromising life itself. They are often characterized by extreme preoccupation with fo...
Anorexia Nervosa and Obesity: A Psychological Health Comparison
The aim of this pilot study was to compare psychopathological features and psychological health between women presenting anorexia nervosa (AN) and those presenting obesity (OB). Six AN patients (Body mass index: BMI <15)...
Physician Death by Suicide: Problems Seeking Stakeholder Solutions
Each year approximately 400 physicians die by suicide in the United States, leaving an estimated one million patients without their physicians [1-5]. Physicians are two to three times more likely to die by suicide than m...
Bupropion Sustained released versus Placebo for seasonal affective Disorder
Background: The majority of seasonal affective disorder (SAD) studies have evaluated the use of light or selective serotonin reuptake inhibitors (SSRI). The purpose of the present study was to evaluate bupropion sustaine...
Different Patterns of Attentional Bias in Subjects with Spider Phobia: A Dot Probe Task using Virtual Reality Environment
Background: Cognitive theories posit that small animal phobics develop a hypervigilance-avoidance attentional pattern when coping with threat. However, empirical research has failed to obtain consistent results. We aimed...