Potential New Pharmacological Approaches in Obese Women with Polycystic Ovary Syndrome
Journal Title: Journal of Diabetes and Obesity - Year 2016, Vol 4, Issue 1
Abstract
Obesity is frequently present in women with polycystic ovary syndrome PCOS It aggravates the adverse features of the syndrome and increases the metabolic risk in this population Weight management by life style intervention often remains unsatisfactory and non-sustainable In the present mini review we revised limited studies addressing the potential use of agents mediating through glucagon-like peptide GLP - 1 in PCOS We reported that short-term intervention with long acting GLP-1 analogue liraglutide is associated with consistent BMI decrease in treatment naive obese women with PCOS and in those who had been previously poor responders to metformin and life style modification Metformin a well-established therapy used in PCOS with high metabolic risk was recognized as a mechanistically well-suited combination with liraglutide Short-term intervention with liraglutide also improved eating behavior in obese PCOS Furthermore we discussed the potential association of genetic variability of GLP-1 receptor and inter-individual differences in response to liraglutide regarding weight reduction In addition we challenged the original concept related to the enhancement of GLP-1 mediated action through phosphordiesterase 4 PDE 4 inhibitions as a new potential therapeutic target in obesity-related population We concluded that GLP-1 mediated agents are promising treatment strategies in the management of obese PCOS However larger sample size studies with longer durations of treatment may be required to examine potential benefits of these medications in decreasing metabolic risk and improving reproductive out come in obese PCOS
Authors and Affiliations
Andrej Janez
Keywords
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- EP ID EP417852
- DOI 10.15436/2376-0494.17.1246
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