Potential of the Combination of a Systemic Enzyme Complex and Probiotics administration to Combat COVID-19: A Randomized Open Label Prospective Analysis
Journal Title: Advances in Clinical Toxicology - Year 2021, Vol 6, Issue 1
Abstract
Background: Enzymes have been used for therapeutic applications for decades owing to their anti-inflammatory and immunomodulatory effects. Probiotics are well known to reduce the incidence and severity of several health-related conditions. To our knowledge, no clinical trial has evaluated the effects of a combination of systemic enzyme and probiotic supplementation in Covid-19 patients infected with the SARSCoV-2 virus. Objective: We investigated the safety and efficacy of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) as supplemental therapy in confirmed mild to moderate COVID-19 patients. Methods: A randomized, open label, 2-arm, prospective study in patients with an RT-PCR confirmed diagnosis of COVID-19 with a mild to moderate condition was conducted. The control arm (n=30) received standard of care (SOC) treatment and the test arm (n=30) received the oral supplements ImmunoSEB (500 mg/cap.) + ProbioSEB CSC3 (5 billion CFUs /cap.) for 14 days in addition to SOC. The efficacy and safety of the experimental regimen was compared with the control arm at various timepoints from days 1 to 21. Results: A significantly higher proportion of patients in the test arm showed clinical improvement on day 10 vs the controls (93.33% vs 60%; p<0.05). No adverse events were reported in the test arm at any time during the study suggesting the safety of supplementation with ImmunoSEB + ProbioSEB CSC3. Patients in the test arm also had a shorter duration of hospitalization, quicker recovery and faster reduction in CRP levels as compared to the control arm. Conclusions: The present study concludes that supplemental therapy with ImmunoSEB + ProbioSEB CSC3 accelerates clinical improvement in mild to moderate COVID-19 patients. While there is no vaccine or specific drug to completely cure SARS CoV-2 infection, the proposed supplemental therapy could be a potential tool to aid in the recovery of COVID-19 of patients.
Authors and Affiliations
Neha Shah*, Rohit Parate and Abhay Vispute
Keywords
Related Articles
- EP ID EP751772
- DOI 10.23880/act-16000205
- Views 1
- Downloads 0
Sled Dogs as a Model for Brown Fat Research
Brown adipose tissue (BAT) has the unique function of burning energy to create heat through the process of non-shivering thermogenesis. Activation of BAT in humans as a means of combating obesity is an active area of re...
Impact of Botulinum Toxin Consultation Shutdown Due to the Covid-19 Pandemic on Spasticity Treatment: A Review of the Literature
Introduction: The COVID-19 pandemic has imposed an additional pressure on health systems worldwide, creating an increased challenge to chronic patient management due to consultation shutdown. Spastic patients were especi...
Dietary Milk Consumption and the Pesticide Residues Exposure from Pasteurized and UHT samples
The multi residue analysis with QuEChERS sample preparation method was employed to evaluate cow milk samples containing up to 3% of fat. After the cleanup step with C18, the pesticides were analyzed by Agilent 7890A GC...
Chronic Fumonisin Intake Induces Erythrocyte Osmotic Fragility
Fumonisin B1 (FB1) is a mycotoxin that appears as a frequent maize and maize-based foods contaminant in Argentina. It has an inhibitory effect of ceramide synthetase, a key enzyme in the biosynthesis of sphingolipids, i...
How to Enhance the Threat Perceptions of Hazardous Chemicals for China’s Urban Residents
Risk communication of technological risk is tough in view of the limitation of the professional requirement for media and knowledge requirement for the individual. This research focuses on the communication dilemma in t...