Potential role of meflquine (antimalarial drug) and methanol extract of Chenopodium ambrosioides and Sesbania sesban in mice infected with Schistosoma mansoni
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2015, Vol 5, Issue 8
Abstract
Objective: To elucidate the efficacy of mefloquine and methanol extract of the plants Chenopodium ambrosioides (C. ambrosioides) and Sesbania sesban (S. sesban) as a combined therapy for the treatment of Schistosoma mansoni (S. mansoni) infected mice, and study the parasitological, biochemical and histological parameters of treated mice. Methods: Two groups of male Swiss Albino mice were infected with S. mansoni cercariae. The first group untreated served as control. The second group was orally treated with a single dose (200 mg/kg) of mefloquine 3 weeks post infection, then subsequently divided into 2 subgroups; the first orally retreated with the plant extracts 1 000 mg/kg of S. sesban followed by 1 250 mg/kg of C. ambrosioides with an 1 h interval, for 2 successive days. The second sub-group was re-treated with the same (dose and method) plant extracts after 7 weeks post infection. Results: The results showed that S. mansoni infected mice treated with mefloquine and the plants’ extracts 3 weeks post infection significantly (P < 0.01) reduced the worm burden/ mouse by 95.5% and the few worms recovered from sacrificed mice in this treatment failed to lay ova. Moreover, no worms were recovered from infected mice treated with mefloquine (3 weeks post infection) and re-treated by the plant’s extracts at 7 weeks post infection. Also, treatment of infected mice with mefloquine followed by the plants’ extracts either at 3 or 7 weeks post infection ameliorated the activities of the serum enzymes alanine aminotransferase, aspartate aminotransferase, alkline phosphatase and acid phosphatase as well as the hepatic granulomatous lesions compared to infected untreated group. Conclusions: It is concluded that successive treatment of S. mansoni infected mice with mefloquine and methanol extract of the plants C. ambrosioides and S. sesban could be a promising device in the strategy of schistosomiasis control.
Evaluation of antibacterial activity of selected medicinal plant extracts from south India against human pathogens
Objective: The present study was to evaluate the antibacterial properties of 21 crude extracts from leaf and flower of Aristolochia indica (A. indica), Cassia angustifolia (C.angustifolia), leaf of Catharanthus roseus (C...
Salmonella spp. and risk factors for the contamination of slaughtered cattle carcass from a slaughterhouse of Bahir Dar Town, Ethiopia
Objective: To assess the prevalence of Salmonella species and associated factors from cattle carcasses in abattoir of Bahir Dar, Ethiopia. Methods: A cross-sectional study was conducted among slaughtered cattle carcass s...
Knowledge on fever and its associated factors among the parents of the children who were treated as cases of dengue fever or dengue hemorrhagic fever in a tertiary care setting of a lower middle income country
Objective: To develop a tool for assessing knowledge on fever and to describe the knowledge and its associated factors of the parents of the children treated as dengue fever/dengue hemorrhagic fever (DF/DHF) at a tertiar...
Pattern of hospital associated infections in a teaching hospital in Nigeria
Objective: This study aimed at investigating the distribution and antibiogram of possible hospital associated pathogens, providing baseline information for the hospital. Methods: Patients with hospital associated infecti...
Larvicidal activity of Phyllanthus emblica Linn. (Euphorbiaceae) leaf extracts against important human vector mosquitoes (Diptera: Culicidae)
Objective: To determine the larvicidal activity of Phyllanthus emblica leaf extracts against Aedes aegypti and Culex quinquefasciatus. Methods: The larvicidal activity was determined against two vector mosquito species a...