Pre-Implantation Immunosuppression in the Pregnant Rat:A Possible Role of Seminal Fluid

Journal Title: Sultan Qaboos University Medical Journal - Year 1999, Vol 1, Issue 1


Successful reproduction involves exposure of the female in significant antigenic challenge. These experiments were done to test the possibility/hypothesis that seminal fluid has an immunosuppressive role in the early stages cf pregnancy, which cculd pretect the conceptus from immonological attack. A highly inbred strain cf rat AO(RTI“) was used in this study. Eleven groups of animals were examined, one during the estrous phase of the ovarian cycle to provide base-line data, five during pseudopregnancy, designated as controls, and five groups during syngeneic pregnancy. Each group contained a minimum of six animals. For each animal, body weight and organ/tissue weightsocf the uterus, thymus, uterine and popliteal lymph nodes, were recorded together with total cell counts of the lympocid tissues and their proliferating cell counts. The material was collected during each of the first five days of pregnancy and pseudopregnancy. The present study supports an immunological suppression by seminal fluid during early pregnancy as shown by a significant sustained depresson of the proliferative lymphocyte response in the uterine regional lymph nodes.

Authors and Affiliations

Omar A. Habbal| Department of Human and Clinical Anatomy, College of Medicine, Sultan Qaboos University. P.O.Box 35, Al-Khod 123, Muscat, Sultanate of Oman, John M. McLean| School of Biological Sciences, University of Manchester, Manchester, U.K.


Related Articles

The Use of Laparoscopy in the Management of Trauma Patients Brief review

Laparoscopy is one of the most effective intervention modalities, resulting in improved outcomes for major surgeries. In the past decade, the laparoscopic approach in trauma patients has shown better diagnostic outcom...

Cerebrospinal Fluid Involvement in a Case of Visceral Leishmaniasis Associated with Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis (HLH) implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal flu...

A Tribute to Professor Musallem EIBuaIy: A Pioneer in Child Health Services

Losing a hero in the early hours of June 25th 1997 filled our heart with sorrow, but also with a great sense of pride for having known and worked with this extraordinary man who transformed health care for children in th...

A Retrospective Study of Fungal Corneal Ulcers in the South Sharqiyah Region in Oman

To study the incidence, identify the risk factors and determine the predominant microorganisms and treatment regimen of fungal corneal ulcers. Methods: Tis was a retrospective analysis of corneal ulcers treated in the Op...

Download PDF file
  • EP ID EP13590
  • DOI -
  • Views 402
  • Downloads 22

How To Cite

Omar A. Habbal, John M. McLean (1999). Pre-Implantation Immunosuppression in the Pregnant Rat:A Possible Role of Seminal Fluid. Sultan Qaboos University Medical Journal, 1(1), 9-16.