Pre-Initiation Effect of Oleuropein towards Apoptotic and Oxidative Stress Levels on the Early Development of Two-Stage Skin Carcinogenesis
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2019, Vol 8, Issue 1
Abstract
Background: Oleuropein is a form of phenolic compound which can be majorly found in the olive leaves. Previous studies have shown several biological functions of oleuropein against different cancer cells. Aim and Objectives: This research was designed to study the pre-initiation effect of oleuropein on the early skin tumour development using a mouse model. Material and Methods: Female Institute of Cancer Research (ICR) mice (n=6 per group) were divided into 2 groups (group 1 as a carcinogen control and group 2 as a vehicle control) and 1 treatment group (group 3: 10 mg/kg of oleuropein). Results:After 10 weeks, Group 3 showed delay in epidermal hyperplasia formation and a significant reduction (p<0.05) in the epidermal thickness as compared to Group 1. Data were also displayed a significant increase (p<0.05) in the apoptotic rate in Group 3 as compared to Group 1 and 2. For biochemical assays, the level of Malondialdehyde (MDA) was significantly (p<0.05) decreased whilst the levels of Glutathione (GSH) and Superoxide Dismutase (SOD) were significantly (p<0.05) increased in Group 3 as compared to Group 1. Conclusion: Our results indicate that pre-initiation treatment of oleuropein may prevent skin tumour development through its antioxidant and apoptotic activities.
Authors and Affiliations
Dayang Noor Suzliana John, Tengku Hasmira Tengku Mamat, Omchit Surien, Izatus Shima Taib, Siti Fathiah Masre
Keywords
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