Pre-stroke statin use was associated with lower risk of in-hospital death in nonthrombolysed patients
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 4
Abstract
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischemic stroke among non-thrombolysed patients. Methods: In this cohort retrospective study we have included 810 ischemic stroke patients (mean age 69.7±11.5, 48.6% females), not-thrombolysed on admission. Based on their prior medication history patients were categorized into pre-stroke statin user and non- statin user patients. The risk of in-hospital mortality was compared between two groups. Results: Of the 810 ischemic stroke patients, 146 (18.2%) were using a statin before stroke. Statin therapy before stroke-onset was associated with a lower risk of in-hospital mortality (3.4% vs. 26.9%), p<0.001. In the multivariable analysis, statin use was independently associated with a favorable outcome (OR = 0.119, 95% CI = 0.047-0.299, p < 0.001). Conclusion: Prior statin therapy in patients with acute ischemic stroke non-thrombolysed patients is associated with lower risk of in-hospital death, and this is independent of other risk factors.
Authors and Affiliations
Nazim Dakaj, Argjend Shala, Fisni Jashari, Dren Boshnjaku, Dardan Jashari, Granit Xhiha, Zylfije Hundozi
Keywords
Related Articles
- EP ID EP40037
- DOI -
- Views 268
- Downloads 0
The adequacy of two sputum smear examinations for diagnosis of Pulmonary Tuberculosis as per RNTCP- A Retrospective study in Pondicherry
Introduction: The failure to promptly identify and treat infectious cases stands out as a critical obstacle in the global control of tuberculosis. The RNTCP ( Revised National Tuberculosis Control Program) guidelines s...
Etiology of Hemoptysis in India Revisited
Aims and Objectives: To study the changing trend in the causes of hemoptysis in India. Materials and Methods: Total of 246 patients complaining of hemoptysis were taken up for this prospective study. The study was appro...
Effect of Health Literacy on Medication Adherence among Diabetic Patients
Introduction:Diabetes mellitus is a major threat in developing countries around the world;thousands of peoples die of diabeticrelated cases due to low medication adherence. Most scholars believe that proper health educat...
Neuromuscular Blocking Effect of Inhalational Anesthetic Agents- A Comparative Study
Introduction: Volatile anesthetics enhance the action of neuromuscular blockade (NMB) by various degrees. The purpose of this study is to compare the muscle relaxant effects of isoflurane and sevoflurane, in the context...
Invasive Squamous Cell Carcinoma Underlying Cutaneous Horn – A Brief Case Report
Cutaneous horn is the clinical description of a hyperproliferation of compact keratin in response to a wide array of underlying benign and malignant pathologic changes. This case report describes a cutaneous horn with a...