Pre-stroke Statin use was associated with lower risk of in-hospital death in nonthrombolysed patients.
Journal Title: International Journal of Medical and Health Sciences - Year 2018, Vol 7, Issue 1
Abstract
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischemic stroke among non-thrombolysed patients. Methods: In this cohort retrospective study we have included 810 ischemic stroke patients (mean age 69.7±11.5, 48.6% females), not-thrombolysed on admission. Based on their prior medication history patients were categorized into pre-stroke statin user and non- statin user patients. The risk of in-hospital mortality was compared between two groups. Results: Of the 810 ischemic stroke patients, 146 (18.2%) were using a statin before stroke. Statin therapy before stroke-onset was associated with a lower risk of in-hospital mortality (3.4% vs. 26.9%), p<0.001. In the multivariable analysis, statin use was independently associated with a favorable outcome (OR = 0.119, 95% CI = 0.047-0.299, p < 0.001). Conclusion: Prior statin therapy in patients with acute ischemic stroke non-thrombolysed patients is associated with lower risk of in-hospital death, and this is independent of other risk factors.
Authors and Affiliations
Nazim Dakaj, Argjend Shala, Fisni Jashari, Dren Boshnjaku, Dardan Jashari , Granit Xhiha, Zylfije Hundozi
Keywords
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