Pre-stroke Statin use was associated with lower risk of in-hospital death in nonthrombolysed patients.
Journal Title: International Journal of Medical and Health Sciences - Year 2018, Vol 7, Issue 1
Abstract
Background: Prior studies suggested that statins might have a neuroprotective effect in patients with acute ischemic stroke. The aim of this study was the evaluation of the short-term effects of statins following ischemic stroke among non-thrombolysed patients. Methods: In this cohort retrospective study we have included 810 ischemic stroke patients (mean age 69.7±11.5, 48.6% females), not-thrombolysed on admission. Based on their prior medication history patients were categorized into pre-stroke statin user and non- statin user patients. The risk of in-hospital mortality was compared between two groups. Results: Of the 810 ischemic stroke patients, 146 (18.2%) were using a statin before stroke. Statin therapy before stroke-onset was associated with a lower risk of in-hospital mortality (3.4% vs. 26.9%), p<0.001. In the multivariable analysis, statin use was independently associated with a favorable outcome (OR = 0.119, 95% CI = 0.047-0.299, p < 0.001). Conclusion: Prior statin therapy in patients with acute ischemic stroke non-thrombolysed patients is associated with lower risk of in-hospital death, and this is independent of other risk factors.
Authors and Affiliations
Nazim Dakaj, Argjend Shala, Fisni Jashari, Dren Boshnjaku, Dardan Jashari , Granit Xhiha, Zylfije Hundozi
Keywords
Related Articles
- EP ID EP40044
- DOI -
- Views 259
- Downloads 0
Use of Closed suction drainage Vs No Drain usage in Orthopaedic surgery- A Prospective Comparative Study
Background: Draining the wound has been followed since the ages with no proved benefits. Objective: To assess the effectiveness of suction drain in Orthopedic surgery and see its effectiveness. Methods:112 patients ,56...
An Unusual Case of Acute Puerperal Uterine Inversion : A Case Report and Review of Literature
Acute uterine inversion is a rare potentially life threatening obstetric emergency. It can present either in the puerperal (obstetric) or non-puerperal (gynaecological) setting. The immediate risk to the patient is due...
Comparative Study of Peak Expiratory Flow Rate in Smokers and Non Smokers
Introduction: Peak expiratory flow rate (PEFR) is a simple index of pulmonary function and can be used in researches, clinical practices and even under field conditions to assess status of large airways. Objectives: The...
Quality of Life in Patients with Diabetes and Hypertension in Karnataka- An Observational Study
Background: Diabetes and Hypertension due to their chronic nature and multi-systemic involvement may affect the quality of life of the patients. Objective: To assess the quality of life among patients with diabetes and...
Pathological Influences of Dysplastic Disturbances for Clinical Manifestations and Surgical Treatment of Pectus Excavatum in Children and Adolescents
Background: The significance of evaluation phenotypic manifestations of dysplastic disturbances are concluded in the choice for the correctional methods of pectus excavatum. Previously, it occurred more frequently that...