Pre-treatment complete blood count as a predictor of overall survival in pediatric patients of age ?18 years presenting with osteosarcoma
Journal Title: Journal of Pakistan Orthopaedic Association - Year 2023, Vol 35, Issue 03
Abstract
Introduction: Osteosarcoma is the most common malignancy of bone. Multi-disciplinary treatment has improved clinical outcomes up to 70%. Factors such as alkaline phosphatase, lactate dehydrogenase, and post-chemotherapy tumor necrosis factor-alpha play a key role in predicting prognosis. However recently, due to cost-effectiveness of inflammatory markers derived from complete blood count have gained popularity in determining survival rates. Methods: The retrospective study was conducted at Children Cancer Hospital/ The Indus Hospital Karachi in pediatric population aged below 18years. 73 patients meeting the inclusion criteria were included in the study who were enrolled from 2005 to 2015. Medical records were reviewed and their survival was analyzed with hematological indices using complete blood count and other medical and surgical variables. Results: Out of these 73 patients, 54.8% were male and survival was found to be 38.4%. The most common site of the presentation was tibia (47.9%). In univariate analysis, pre treatment hemoglobin levels, completion of neoadjuvant therapy and adjuvant therapy, pathological fracture on presentation, metastasis, surgery performed, TLC ?0.6875, NC ?0.471, and LC ?0.2343 were found to be significant risk factors of death. In multivariate analysis metastasis during or after treatment, hemoglobin levels <11mg/dl and TLC ?0.6875 were the found to be the major factors of death. Conclusion: None of the pre-treatment indices taken from CBC proved to predict survival except hemoglobin (<11 mg/dl) and TLC (?0.6875) which were associated with an increased risk of disease progression along with metastasis either during or after treatment
Authors and Affiliations
Syed Ali Anwar Jillani1, Salman Javed2, Muhammad Rafie Raza3, Muhammad Amin Chinoy4, Syed Kamran Ahmed5
Keywords
Related Articles
- EP ID EP740850
- DOI -
- Views 50
- Downloads 0
Surface Matters: Nanotechnology in Orthopaedics and Spine
Implant surface geometry is important for biological response from surrounding tissue smooth surface to rough to nano-surface have variable response – from cellular and protein adsorption and bony integration, as one cha...
Functional Outcome of Dual Mobility Cup in Complex Primary Hip Arthroplasty - Our Experience from Developing World
Introduction: Instability following total hip arthroplasty (THA) is the most common indication of revision surgery globally. It is peculiarly prevailing among high-risk patients such as those with neuromuscular disorders...
Spinal Tuberculosis: Decompression and Stabilization by single posterior approach: A Multi-Centric Cohort study
Objective: To determine functional and fusion outcomes of postero-lateral decompression in spinal tuberculosis. Methods: This multi-centric study was done from January 2014 to December 2017. We included 52 patients wi...
The Modified Trap Door Procedure with Arthrodiastasis for Avascular Necrosis of Femoral Head
Objective: To investigate the functional outcomes of modified trap door procedure with arthrodiastasis for avascular necrosis of femoral head. Methods: This case series study was conducted at Orthopaedic Surgery Depar...
CTX1 is A Better Index to Evaluate The Severity of Osteoporosis then Radiographic Index
To illustrate that CTX1 is the far better tool to evaluate the severity of osteoporosis then radiographic index (Singh index) in perimenopausal women. Material and Methods: This descriptive cross sectional study was done...