Preclinical evaluation of the diabetic wound healing activity of phytoconstituents extracted from Ficus racemosa Linn. leaves
Journal Title: International Journal of Experimental Research and Review - Year 2023, Vol 32, Issue 3
Abstract
Human body has several multi-layered organs, but skin is one of biggest and easiest to access. It serves as body's primary line of defense alongside various skin diseased conditions. Despite receiving sufficient and appropriate care, diabetes wounds heal slowly and may take a week to complete. A progression of connective tissue patch up is the body's natural defense against tissue damage. Fresh leaves of Ficus racemosa were utilized for the study. In this study, two distinct models were employed to compare how well different Ficus racemosa leaf extracts healed wounds. Excision wounds healed more quickly and to a greater extent after being treated with a flavonoid and tannin fraction of Ficus racemosa leaf extract, suggesting improved epithelization. The extract-treated groups also experienced an increase in breaking potency of incision wounds made; higher breaking strength indicates better wound healing. Complete closure of wound of flavonoid fraction and in fraction of Ficus racemosa extract occurred in 16 and 17 days respectively. Standard treatment increased tensile strength in the diabetic linear incision wound model, followed by treatment with the flavonoid fraction and tannin fraction of Ficus racemosa leaves extract. Ultimate finding and outcome of the present study experimentally demonstrates that extracts of the flavonoid and tannin fractions of Ficus racemosa have wound-healing properties and are effective in treating diabetic wounds. From this study, we state that Ficus racemosa flavonoid fraction and tannin fraction extract has a beneficial effect on blood glucose levels, which shows hypoglycaemic activity.
Authors and Affiliations
Sadhana Pawar, Kajal Pawade, Sonali Nipate, Aishawarya Balap, Bhushan Pimple, Vijay Wagh, Ramanlal Kachave, Asmita Gaikwad
Keywords
Related Articles
- EP ID EP720682
- DOI 10.52756/ijerr.2023.v32.032
- Views 33
- Downloads 0
Enhancing Sign Language Understanding through Machine Learning at the Sentence Level
The visual language of sign language is based on nonverbal communication, including hand and body gestures. When it comes to communicating, it is the main tool for those who are deaf or hard of hearing all around the glo...
The Voltage stability analysis for grid-connected PV system using optimized control tested by IEEE 14 &30 bus system
In the research work presented in this paper, we present a grid-connected solar photovoltaic (PV) system, which is focused on various factors, such as the low oxide emission and high energy efficiency of the system. Sola...
Occurrences of seven new records of goat fishes (family: Mullidae) from the coastal waters ofWest Bengal, India
Thirty eight fish specimens of family Mullidae were collected during the ornamental faunal survey around the West Bengal coast. All these specimens were identified into seven species which are addition to the faunal reso...
Exploring the Potency of Antiviral Marine Alkaloids Against Japanese encephalitis and Ebola virus: A Computational-Based Assessment for Drug Repurposing Applications
In the twenty-first century, there have been a number of outbreaks, beginning with dengue, swine flu, Nipah, Ebola, chikungunya, and Zika, which were continuously outbreaks in some specific regions. The mosquito-transmit...
Microstrip Planar Antennas for C-Band Wireless Applications
In recent years, wireless communications have evolved significantly, and many mobile devices have reduced in size. The antennas used in mobile terminals must be lowered in size to fulfil the downsizing standards. Planar...