Predicting Binding Between Main Molecules of Iranian Oliveria decumbens and DPP-4 Enzyme Using Molecular Docking
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 2
Abstract
Received 09 January 2018 Revised 20 January 2018 Accepted 22 January 2018 Published online 07 February 2018 Type 2 Diabetes (T2D) is an endocrine disease affecting millions of humans around the world, causing many damages to human health. Many drugs are used for the treatment of T2D, but they have many secondary effects. Natural products, especially from plants, can be sources of important bioactive molecules which can serve as an alternative to T2D treatment. Constituent molecules of essential oil from Iranian Oliveria decumbens were investigated for their capacity to inhibit Dipeptidyl-Peptidase 4 (DPP-4) enzyme which has been implicated in type 2 diabetes. Formation of stable complexes between enzyme and ligands was carried out using molecular docking. The energy of the complexes formed was also calculated. The compounds with the lowest energy were predicted to have the best binding. The results obtained predicted myristicin to be the best binder of DPP-4 enzyme.
Authors and Affiliations
Salim Bouchentouf, Ebrahim Talebi
Keywords
Related Articles
- EP ID EP489353
- DOI 10.26538/tjnpr/v2i2.9
- Views 90
- Downloads 0
Brine Shrimp Cytotoxicity and Anti-Mitotic Activity of Aqueous Root-Bark extract of Securidaca longepedunculata (Polygalaceae
Received 12 July 2017 Revised 13 February 2018 Accepted 21 February 2018 Published online 07 March 2017 Securidaca longepedunculata is a savannah shrub found growing in South-West Nigeria and some other areas in Africa....
Larvicidal Assessment of Fractions of Aristolochia albida Rhizome on Culex quinquefasciatus
Received 18 April 2018 Revised 03 May 2018 Accepted 07 May 2018 Published online 10 May 2018 Aristolochia albida is a plant, native of Africa that has found various applications including antiparasite and anti-snake ven...
Antiglycation and Antioxidant Activity of Funtumia africana Root Used in the Management of Diabetes
Received 04 April 2018 Revised 07 May 2018 Accepted 08 May 2018 Published online 10 May 2018 Funtumia africana (Benth.) Stapf (Apocynaceae) is used folklorically for the treatment of various ailments such as dysentery,...
Antimalarial Activity of the n-Butanol Fraction of Uapaca togoensis (Pax) Stem Bark in Mice
The stem bark extract of Uapaca togoensis has been used in traditional medicine for the management of fever, epilepsy, fatigue and rheumatism. This study was aimed at evaluating the in vivo antimalarial activity of the n...
Isolation and Characterisation of Lup-20(29)-en-3β-ol from the Methanol Stem Bark Extract of Bombax costatum pv (Bombacacea)
Bombax costatum, a plant widely distributed in the Sahel savannah of West Africa is well known for its traditional use as a diuretic. This study is aimed at isolation, purification and characterization of phytoconstituen...