Predicting the Effects of Anti-angiogenic Agents Targeting Specific VEGF Isoforms
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-012-9363-4) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Stacey D. Finley, Aleksander S. Popel
Keywords
Related Articles
- EP ID EP681236
- DOI 10.1208/s12248-012-9363-4
- Views 70
- Downloads 0
Rapid Sample Size Calculations for a Defined Likelihood Ratio Test-Based Power in Mixed-Effects Models
Efficient power calculation methods have previously been suggested for Wald test-based inference in mixed-effects models but the only available alternative for Likelihood ratio test-based hypothesis testing has been to p...
Population Pharmacokinetics of Telapristone (CDB-4124) and its Active Monodemethylated Metabolite CDB-4453, with a Mixture Model for Total Clearance
Telapristone is a selective progesterone antagonist that is being developed for the long-term treatment of symptoms associated with endometriosis and uterine fibroids. The population pharmacokinetics of telapristone (CDB...
Model-Based Decision Making in Early Clinical Development: Minimizing the Impact of a Blood Pressure Adverse Event
We describe how modeling and simulation guided program decisions following a randomized placebo-controlled single-rising oral dose first-in-man trial of compound A where an undesired transient blood pressure (BP) elevati...
NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity
Sirtuins are recently discovered NAD+-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins, thereby regulating the biological function of their targets. Sirtuins have been shown to increas...
Empirical and Semi-Mechanistic Modelling of Double-Peaked Pharmacokinetic Profile Phenomenon Due to Gastric Emptying
Models have been developed to explain double-peaked plasma concentration-time profiles using mechanisms such as variable absorption and enterohepatic recirculation. Interruption of gastric emptying has also been shown to...