Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans

Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 5

Abstract

The online version of this article (doi:10.1208/s12248-014-9636-1) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Chelsea M. Hosey, Fabio Broccatelli, Leslie Z. Benet

Keywords

Related Articles

Shear-induced variability in the United States pharmacopeia apparatus 2: Modifications to the existing system

The hydrodynamics within the United States Pharmacopeia Apparatus 2 have been shown to be highly non-uniform with a potential to yield substantial variability in dissolution rate measurements. Through the use of readily...

A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole

The development of vaginal medications, especially antifungal medications, requires that the drug is solubilized as well as retained at or near the mucosa for sufficient periods of time to ensure adequate bioavailability...

Novel Lansoprazole-Loaded Nanoparticles for the Treatment of Gastric Acid Secretion-Related Ulcers: In Vitro and In Vivo Pharmacokinetic Pharmacodynamic Evaluation

The objective of this study is to combine nanoparticle design and enteric coating technique to sustain the delivery of an acid-labile drug, lansoprazole (LPZ), in the treatment of acid reflux disorders. Lansoprazole-load...

A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine

The minor tobacco alkaloids nornicotine, anabasine, and anatabine fromNicotiana tobacum are known to possess nicotinic receptor agonist activity, although they are relatively less potent than S-(−)-nicotine, the...

Download PDF file
  • EP ID EP681674
  • DOI  10.1208/s12248-014-9636-1
  • Views 85
  • Downloads 0

How To Cite

Chelsea M. Hosey, Fabio Broccatelli, Leslie Z. Benet (2014). Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans. The AAPS Journal, 16(5), -. https://europub.co.uk/articles/-A-681674