Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 5
Abstract
The online version of this article (doi:10.1208/s12248-014-9636-1) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Chelsea M. Hosey, Fabio Broccatelli, Leslie Z. Benet
Mapping the Target Localization and Biodistribution of Non-Radiolabeled VMAT2 Ligands in rat Brain
Imaging targeting vesicular monoamine transporter (VMAT2) alterations is a sensitive tool for early diagnosis of Parkinson’s disease. Our group has reported several novel 2-amino-DTBZ derivatives as potential VMA...
Direct and Rapid Genotyping of SLCO1B1 388A>G and 521T>C in Human Blood Specimens Using the SmartAmp-2 Method
Organic anion-transporting polypeptide (OATP) 1B1, encoded by the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene, mediates the active uptake of various organic anions into hepatocytes and deter...
High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA
The online version of this article (doi:10.1208/s12248-015-9812-y) contains supplementary material, which is available to authorized users.
Release and permeation kinetics of caffeine from bioadhesive transdermal films
The aim of this work was to investigate, in vitro, the kinetics of release and permeation of caffeine, chosen as model drug, from bioadhesive transdermal films. These films are not self-adhesive but become adhesive when...
Receptor-targeted gene delivery viafolate-conjugated polyethylenimine
A novel synthetic gene transfer vector was evaluated for tumor cell-specific targeted gene delivery. The folate receptor is a tumor marker overexpressed in more than 90% of ovarian carcinomas and large percentages of oth...