Prediction of Disease Severity by Beta 2 Microglobulin Levels In Hodgkin Lymphoma
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 3
Abstract
Hodgkin's lymphoma (HL) also known as Hodgkin lymphoma or Hodgkin's disease is a type of lymphoma, in which cancer originates from a specific type of white blood cells, called B lymphocytes. When lymph nodes of Hodgkin’s lymphoma are examined microscopically, multinucleated Reed–Sternberg cells (RS cells) are the characteristic histopathological finding. In this study we studied the role of beta 2 microglobulin (B2M) as a marker of disease severity in Hodgkin lymphoma. 30 patients, diagnosed with Hodgkin lymphoma and 30 age and sex matched healthy controls were included in this study. All patients were given 6 cycles of ABVD regimen. Sample was analysed for routine biochemistry and B2M. B2M levels were estimated by a commercial Enzyme Linked Immunosorbent Assay kit for human B2M (DRG β2-MG ELISA). Mean serum B2M was 0.40± 0.38 µg/ml in controls. Levels were significantly raised in HL patients (4.20±1.88µg/ml, p<0.01).In this study 13(43.34%) patients presented with late stage (III + IV) and 17(56.66%) patients presented with early stage (I + II). It was found that patients with late stage had comparatively higher mean B2M levels (7.02±0.023µg/ml) as compared to those earlier stages(3.2±0.065µg/ml).This correlation was found to be statistically significant (p<0.01). Male patients suffering from HL had higher B2M (4.83±1.24 µg/ml) levels as compared to females (3.89±1.32 µg/ml) but the difference was statistically not significant. Patients with mediastinal large lymphnodes (bulky lymphadenopathy) had higher B2M levels (5.11±0.22 µg/ml) as compared to other HL patients (3.65±0.16, p <0.05 µg/ml).HL patients who presented with B symptoms had higher B2M levels (4.81±0.20 µg/ml) as compared to those without B symptoms (4.11±0.65, p>0.05 µg/ml). The conclusion in our study, B2M was found to be significantly associated with the severity of disease. Though, B2M has been discovered long time back but its role as a marker for the severity of disease has not been studied extensively, so still larger studies with longer follow up are required to validate its role in Hodgkin lymphoma as a disease severity marker. Keywords: Hodgkin lymphoma, beta2 microglobulin, stages, lymphnodes.
Authors and Affiliations
Garima Gupta, V. Lokanathan, V S Ghalaut, Madhumita Sarkar, Tarun Sharma, Sumit Dokwal
Keywords
Related Articles
- EP ID EP372366
- DOI -
- Views 75
- Downloads 0
Antioxidant activity study of pleurotus eryngii polysaccharide
Abstract: The antioxidant ability of pleurotus eryngii polysaccharide was investigated in the experiment and was compared with vitamin C. The results showed as followed. In terms of reducing power and hydroxyl radical sc...
Finger Prosthesis Made Easy: A Case Report
Hand is a body part which is of major importance for communication, body language and social contact along with its basic function of grasping and feeling. Finger and partial finger amputations are some of the most frequ...
A Prospective Study on Accidental Poisoning In Pediatric Patients
Toxicology is the science which deals with the chemical properties, action, toxicity, lethal dose, detection of various poisons and treatment of poisons. Poison is any substance which when introduced in to the living bod...
Extensive Intraductal Component (EIC) Positive Carcinoma of Breast-Four Years’ Experience at a Cancer Centre
Abstract:Extensive intraductal component positive carcinoma (EICPC) of breast is a well defined entity. Nevertheless few data exist concerning their characteristics and prognostic behaviour. Our objective was to describ...
Accumulation of Fluoride from Natural Water Sources in Oreochromis mossambicus (Peters, 1852)
O. mossambicus (Tilapia) samples from five study sites Ernakulam, Alappuzha town, Mannancherry, Ambalappuzha and Kuttanad were analyzed for the fluoride content. The water from which the fishes were collected was also an...